Analysis of Predictive Value of Combined Detection of Serum Cystatin C and Total Bilirubin in the Prognosis of High-risk Non-ST-segment Elevation Myocardial Infarction
Abstract：【Objective】To explore the prognostic value of combined detection of serum cystatin C (cys C) and total bilirubin (TBIL) in the prognosis of high-risk non-ST-segment elevation myocardial infarction (NSTEMI). 【Methods】 The clinical data of 173 patients with NSTEMI who underwent percutaneous coronary intervention (PCI) treatment in our hospital from November 2018 to November 2020 were retrospectively analyzed. Serum cys C and TBIL levels were detected before PCI. Patients were followed up for 28 days to record the incidence of the patients' major adverse cardiovascular events (MACE). According to whether the patients had MACE at 28 days after operation, they were divided into the occurrence group (occurrence of MACE) and non-occurrence group (non-occurrence of MACE). General patient information was collected. Logistic regression analysis was used to analyze the risk factors of MACE in NSTEMI patients within 28 days after PCI. The receiver operating characteristic curve (ROC) was drawn, and the area under curve (AUC) was used to evaluate the predictive value. 【Results】Within 28 days after the operation, 29 of the 173 patients had MACE. The incidence of MACE was 16.76%. The age of > 65 years old, Killip grade (Ⅲ-Ⅳ), the proportion of cases with culprit blood vessels ≥2, and the pre-PCI blood levels of creatinine, N-terminal B-type brain natriuretic peptide (NT-proBNP), uric acid (UA), serum cys C and TBIL in the occurrence group were higher than those in the non-occurring group (P<0.05). Logistic regression analysis showed that age>65 years old, number of culprit blood vessels ≥2, serum cys C and TBIL levels before PCI were risk factors for MACE in NSTEMI patients within 28 days after PCI (P<0.05).ROC results showed that the serum cys C and TBIL levels before PCI, and the combination of both cys C and TBIL detection for predicting the AUC values of MACE in NSTEMI patients within 28 days after PCI were 0.785, 0.744,and 0.915 (all P<0.05). 【Conclusion】The detection of both serum cys C and TBIL levels before PCI has a certain value in predicting the occurrence of MACE in NSTEMI patients within 28 days after PCI, while the combined detection of cys C and TBIL has even higher predictive value.
顾佳宁, 刘丹, 邸若岷, 徐迎佳. 血清胱抑素C及胆红素联合检测对高危非ST段抬高型心肌梗死患者预后的预测价值分析[J]. 医学临床研究, 2023, 40(12): 1850-1853.
GU Jianing,LIU Dan,DI Ruomin,et al. Analysis of Predictive Value of Combined Detection of Serum Cystatin C and Total Bilirubin in the Prognosis of High-risk Non-ST-segment Elevation Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2023, 40(12): 1850-1853.
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2023, Vol. 40 
