Effect of Oxycodone Combined with Dexmedetomidine in General Anesthesia on Anesthesia Related Indexes in Patients with Increased Serum Direct Bilirubin and Alkaline Phosphatase
FENG Yu, CHEN Chen LU Hai-tao, et al
The Langfang People's Hospital, Langfang, Hebei 065000
Abstract：【Objective】To investigate the effect of combined use of oxycodone and dexmedetomidine (Dex) in general anesthesia on anesthesia related indexes in patients with increased serum direct bilirubin (DBIL) and alkaline phosphatase (ALP).【Methods】Sixty cases of patients with increased DBIL and ALP caused by obstructive jaundice or liver cell jaundice were selelcted, and the patients were divided into control group (M group) and oxycodone combined with Dex group (Q group). The M group received combined inhalation and intravenous anesthesia while the Q group were treated with intravenous infusion of oxycodone 4mg at 10min before induction of anesthesia and infusion of Dex 0.5 μg/(kg·h) till 25 min before skin closure. The anesthesia related situation between the two groups was compared.【Results】There was no significant difference in extubation time between the two groups (P>0.05), and the total amount of propofol and remifentanil in the group Q was less than that in the group M (P<0.05);In the group Q, 1min (T1) after intubation, 1min (T2) after extubation, heart rate (HR) and mean arterial pressure (MAP) at 10min (T3) after extubation were lower than those in the group M, and the difference was significant (P<0.05);In the group Q, the visual analogue scale (VAS) at extubation and 10min after extubation was lower than that in the group M, and the Ramsy score was higher in group than that in the group M (P<0.05);The incidence of restlessness, hypotension and bradycardia in the group Q was slightly lower than that in the group M, and the respiratory depression was slightly higher than that in the group M, but the difference was not significant (P>0.05).【Conclusion】The application of oxycodone hydrochloride combined with Dex in general anesthesia for patients with increased serum DBIL and ALP caused by jaundice can maintain hemodynamic stability, and reduce the dosage of propofol and remifentanil.
冯宇,陈晨,鲁海涛,刘海燕,王晓蕾,刘贺佳. 羟考酮与右美托咪定联用对血清DBIL和ALP增高患者全麻中相关指标的影响[J]. 医学临床研究, 2017, 34(10): 1892-1894.
FENG Yu, CHEN Chen LU Hai-tao, et al. Effect of Oxycodone Combined with Dexmedetomidine in General Anesthesia on Anesthesia Related Indexes in Patients with Increased Serum Direct Bilirubin and Alkaline Phosphatase. JOURNAL OF CLINICAL RESEARCH, 2017, 34(10): 1892-1894.
2017, Vol. 34 
