Abstract：【Objective】To investigate the factors influencing early neurological deterioration(END) in acute large artery atherosclerotic(LAA) stroke. 【Methods】A total of 194 LAA stroke patients admitted to the two hospitals were enrolled in the study. Based on whether END occurred during hospitalization,patients were divided into the END group(n=68) and the non-END group(n=126). Clinical data and relevant laboratory test indicators of both groups were compared between the two groups. Multivariate logistic regression was used to analyze the factors related to END,and the receiver operating characteristic(ROC) curve was applied to evaluate the predictive value of clinical indicators for END. 【Results】The systolic and diastolic blood pressures as well as the National Institutes of Health Stroke Scale(NIHSS) scores upon admission in the END group were significantly higher than those in the non-END group(P<0.05).The low-density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbA1c),and homocysteine(Hcy) levels in the END group were significantly higher than those in the non-END group(P<0.05).Multivariate logistic regression analysis showed that the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c were correlated with END. Their odds ratios (OR) were 3.22,1.03,1.08 and 1.83,respectively.ROC analysis indicated that the predictive value areas under the curve(AUC) for the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c for END were 0.89,0.76,0.71,and 0.81,respectively. 【Conclusion】Factors influencing END in acute LAA stroke include the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c. These factors possess predictive value for END.
2023, Vol. 40 
