Abstract：【Objective】To investigate the correlation between premature ovarian failure (POF) and psychological, social, and iatrogenic factors in reproductive-age women.【Methods】 A retrospective analysis was conducted on the clinical data of 80 POF patients admitted to the Xi'an Maternal and Child Health Hospital from January 2019 to January 2021 (observation group), and 127 healthy women who underwent health examination in the same period were selected as the control group. General information was compared between the two groups, and multiple factor logistic regression analysis was used to identify risk factors for POF in reproductive-age women. Pearson correlation analysis was used to analyze the correlation between POF and related factors. 【Results】The observation group had significantly higher scores on the Social Anxiety Scale (ASA) and Beck Depression Inventory (BDI), as well as a higher proportion of ovarian surgery history, pelvic surgery history, and use of contraceptives compared to the control group (P<0.05). Multivariate logistic regression analysis showed that social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives were risk factors for POF in reproductive-age women (P<0.05). Pearson correlation analysis showed a positive correlation between POF and social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives in reproductive-age women (P<0.05). Analysis of the receiver operating characteristic curve showed that social anxiety, depression, ovarian surgery history, pelvic surgery history, and use of contraceptives had high predictive efficiency, with area under the curve of 0.821, 0.871, 0.561, 0.634, and 0.613, respectively. 【Conclusion】The incidence of POF in reproductive-age women is related to factors such as social anxiety, depression, ovarian surgery history, pelvic surgery history, etc. Clinical medical workers need to start with the etiology to develop reasonable treatment plans and thereby improve the reproductive health and quality of life of POF patients in reproductive-age women.
2023, Vol. 40 
