Abstract：【Objective】To investigate the relationship of coronary artery thrombus burden with serum cystatin C (cys C) and D-dimer(D-D) levels in patients with acute myocardial infarction (AMI). 【Methods】Fifty patients who underwent coronary angiography (CAG) for AMI were selected as the observation group, and another 50 patients with chest pain symptoms but having completely normal CAG results were selected as the control group. The lipid profile, cys C, and D-D levels were compared between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of cys C and D-D for AMI. The observation group was further divided into a low thrombus burden group (n=21, thrombus grades 0-3) and a high thrombus burden group (n=29, thrombus grades 4-5) based on the coronary artery thrombus burden evaluation. The cys C and D-D levels were compared between the two groups, and their diagnostic value for high thrombus burden in AMI patients was analyzed. 【Results】The levels of triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) in the observation group were higher than those in the control group, while the level of high-density lipoprotein cholesterol (HDL-C) was lower (P<0.05). However, there was no significant difference in total cholesterol (TC) levels between the two groups (P>0.05). The levels of cys C and D-D in the observation group were significantly higher than those in the control group (P<0.05). The areas under the ROC curves for cys C and D-D in diagnosing AMI were 0.955 and 0.959, respectively. Compared to the low thrombus burden group, the high thrombus burden group had higher levels of cys C and D-D (P<0.05). The areas under the ROC curves for cys C and D-D in diagnosing high thrombus burden in AMI patients were 0.920 and 0.928, respectively. 【Conclusion】cys C and D-D levels are significantly elevated in patients with AMI, and their levels are higher in patients with high thrombus burden. Both cys C and D-D measurement have a high diagnostic value for both AMI and high thrombus burden.
李锦锦. 胱抑素C及D二聚体水平与急性心肌梗死患者冠状动脉血栓负荷的关系[J]. 医学临床研究, 2023, 40(10): 1522-1525.
LI Jinjin. Study on Relationship of Coronary Artery Thrombus Burden with Levels of Cystatin C and D Dimer in Acute Myocardial Infarction. JOURNAL OF CLINICAL RESEARCH, 2023, 40(10): 1522-1525.
[1] 张玉萍,刁秀林,黄雪华,等. D-二聚体与急性心肌梗死患者住院期间发生心血管事件的相关性研究[J].实用中西医结合临床,2022,22(16):77-79. [2] 钟远娟,吉训宁,王文菊,等. 血清半乳糖凝集素3、脂联素、胱抑素C水平预测急性心梗患者出现心力衰竭的临床价值[J].中国急救复苏与灾害医学杂志,2021,16(7):732-735. [3] STENGAARD C, SORENSEN J T, RASMUSSEN M B, et al.Prehospital diagnosis of patients with acute myocardial infarction[J].Diagnosis (Berl),2016,3(4):155-166. [4] 李卓民,盛如丰. 心肌梗死患者PCI术后adiponectin、D-dimer表达水平与预后的相关性[J].河北医药,2021,43(20):3126-3128. [5] 陈金图,刘禹,吴聪莲,等. HCY、FDP、D-Dimer与PLT聚集功能联合检测在AMI早期临床诊断的应用[J].中国卫生标准管理,2021,12(18):49-52. [6] 阮甜甜,沈利民,周小惠. 血浆D-二聚体水平对急性心脑血管疾病的诊断价值分析[J].中国医药科学,2020,10(21):184-187. [7] 陈科. 床旁检测心梗三项与D-二聚体在心脑血管疾病早期诊断及预后中的临床价值[J].临床医学研究与实践,2019,4(20):85-86. [8] 郭建萍,王华. 初诊急性心梗患者血清N末端脑钠肽及D-二聚体水平与预后的相关性研究[J].实验与检验医学,2020,38(3):561-563. [9] 苑广洋,田凤石,刘勇,等. hs-CRP联合D-二聚体对急性心梗PCI术后亚急性支架内血栓形成的预测价值[J].天津医药,2018,46(10):1058-1062. [10] 佟长君. 急性心肌梗死泵衰竭患者血清胱抑素C水平的临床意义探讨[D].沈阳:中国医科大学,2018. [11] ZHANG N, SHI F, LIANG H, et al. The feasibility of using Hcy, CRP, and Cys-C to analyze AMI patients' disease conditions and prognoses[J].Am J Transl Res,2021,13(4):2724-2730. [12] DING M, LI M, YANG H. Clinical diagnostic value of combined detection of IMA, D-D and MCP-1 in acute myocardial infarction[J].Exp Ther Med,2021,21(5):457. [13] 魏淑岩,胡文宇. 血清胱抑素C与急性心肌梗死患者心功能关系的研究[J].中西医结合心血管病电子杂志,2014,2(8):5-6. [14] 李军,徐朝,郭志强,等. 血浆D-二聚体水平检测在急性肺栓塞与急性心梗鉴别诊断中的应用[J].中国卫生检验杂志,2014,24(14):2120-2122.
2023, Vol. 40 
