Abstract：【Objective】To explore levels of serum glial fibrillary acidic protein (GFAP) and S100 protein B (S100B) and their correlation with brain damage in premature infants.【Methods】A total of 94 premature infants who were born in our hospital between March 2019 and March 2021 were selected and they were divided into the occurrence group (n=38 cases) and non-occurring group (n=56 cases) according to whether brain damage occurred. The levels of serum GFAP and S100B plus Apgar scores were compared in both groups. Then,the levels serum GFAP and S100B,and Apgar scores of premature infants with different severity of brain damage were compared. Pearson correlation was used to analyze the correlation of serum GFAP and S100B levels in brain injury children with their Apgar scores at 5 minutes after birth. The receiver operating characteristic (ROC) curve was used to analyze the value of serum GFAP and S100B levels at 12 hours after birth in assessing brain damage in premature infants.【Results】The serum levels of GFAP and S100B at 12 hours and 3 days after birth in the occurrence group were higher than those in the non-occurrence group at 12 hours and 3 days after birth (P<0.05). The serum levels of GFAP and S100B at 3 days after birth in the two groups were lower than that at 12 hours after birth (P<0.05). The Apgar score at 5 minutes after birth in the occurrence group was lower than that in the non-occurrence group (P<0.05). The levels of serum GFAP and S100B in the severe group were higher than those in the mild and moderate groups (P<0.05),while those in the moderate group were higher than those in the mild group (P<0.05); The Apgar score at 5 minutes after birth in the severe group was lower than that in the mild and moderate groups (P<0.05),while the Apgar score in the moderate group was lower than that in the mild group (P<0.05). Pearson correlation analysis showed that serum GFAP and S100B levels in children with brain injury at 12 hours and 3 days after birth were negatively correlated with Apgar score at 5 minutes after birth (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) for assessing brain injury in preterm infants with serum GFAP and S100B levels at 3 and 12 hours after birth were 0.848,0.866,0.908,and 0934,respectively (all P<0.05).【Conclusion】Serum GFAP and S100B levels are related to brain damage in premature infants,which can be used as sensitive indicators to assess brain damage in premature infants.
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2023, Vol. 40 
