Effects of Hyaluronic Acid Repair Biofilm Combined with Pimecrolimus on Serum Biochemical Parameters and Skin Barrier Function in Patients with Allergic Dermatitis
LIU Lin, XIANG Sheng-ping, PAN Bai-li , et al
Hospital of Chengdu Office of People's Government of Tibet Autonomous Region,Chengdou Sichuan 610041
Abstract：【Objective】To investigate the effect of hyaluronic acid repair biofilm combined with pimecrolimus on serum biochemical parameters and skin barrier function in patients with allergic dermatitis. 【Methods】 Eighty-six patients with allergic dermatitis from January to December 2015 were selected and randomly divided into observation group and control group with 43 cases in each group. The control group was given pimecrolimus ointment for external application, while the observation group was treated with hyaluronic acid repair biofilm on the basis of the control group. After 4 weeks of treatment, the clinical symptom scores, serum biochemical indicators, skin barrier function and clinical efficacy of the two groups were compared.【Results】The clinical symptom score of the observation group was significantly lower than that of the control group (t=8.437,P<0.05); the effective rate was significantly higher than that of the control group (χ2=6.081, all P<0.05); the serum levels of interleukin-4 (IL-4), interleukin-13 (IL-13), immunoglobulin (IgE) were significantly lower than those of the control group (t=12.050, 5.167, 4.219, all P<0.05); the transdermal water loss (TWEL) was significantly lower than that of the control group, and the TWEL was significantly lower than that of the control group. The water content and oil content in cuticle were significantly higher than those in thecontrol group (t=4.491, 3.363, 13.036,P<0.05).【Conclusion】Hyaluronic acid repair biofilm combined with pimecrolimus can help alleviate the clinical symptoms of patients with allergic dermatitis and improve the therapeutic effect, which may be related to reducing the content of serum inflammatory factors, regulating immune function and restoring skin barrier function.
刘琳, 向省平, 潘柏莉, 陈艳. 透明质酸修护生物膜联合吡美莫司对变应性皮炎患者血清生化指标及皮肤屏障功能的影响[J]. 医学临床研究, 2019, 36(3): 469-471.
LIU Lin, XIANG Sheng-ping, PAN Bai-li , et al. Effects of Hyaluronic Acid Repair Biofilm Combined with Pimecrolimus on Serum Biochemical Parameters and Skin Barrier Function in Patients with Allergic Dermatitis. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 469-471.
[1] 易文娟,梁虹,谢婷,等.复方红参肽原液电离子导渗对面部敏感性皮肤的辅助疗效观察[J].实用皮肤病杂志,2013,6(5):277-280. [2] Zane C, Facchinetti E, Rossi MT,et al. A randomized clinical trial of photodynamic therapy with methyl aminolaevulinate vs. diclofenac 3% plus hyaluronic acid gel for the treatment of multiple actinic keratoses of the face and scalp [J].Br J Dermatol,2014, 170(5): 1143-1150. [3] 李瑞玲,张理涛.敏感性皮肤的临床诊断、中西医结合治疗和护理[C].第五届全国中西医结合变态反应学术会议论文集,2013, 5:162-163. [4] 李淑媛,王学民.自我感知性敏感性皮肤的机制及其评判[J].实用皮肤杂志,2013,6(6):351-353. [5] 赵静,黄威,王燕,等.中胚层疗法在治疗面部敏感性皮肤的临床应用[J].中国血液流变学杂志,2016,26(2):195-197. [6] 于新,单秀娟,赵学良,等.透明质酸修护生物膜联合吡美莫司乳膏对面部糖皮质激素依赖性皮炎的疗效观察[J].临床肺科杂志,2016,45(6):469-471. [7] Esser PR, Wolfle U, Durr C, et al. Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation [J].PLoS One,2012, 7(7): e41340. [8] 郭文军,宫庆娟.臭氧灌注联合透明质酸钠注射对膝骨关节炎患者疼痛程度及关节液中相关介质的影响[J].海南医学院学报,2016,22(7):669-672. [9] Kwon SS, Kong BJ, Park SN. Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose-hyaluronic acid and for applications as transdermal delivery systems for skin lesions [J].Eur J Paharm Biopharm,2015, 92: 146-154. [10] 李娜,施为,杨森,等.透明质酸修护生物膜与舒敏保湿修复霜辅助治疗敏感性皮肤随机对照观察[J].临床肺科杂志,2013,42(12):735-738. [11] Jung AR, Ahn SH, Park IS, et al. Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4 [J].BMC Complement Altern Med,2016, 16(1): 416.
2019, Vol. 36 
