Abstract：【Objective】 To investigate the dynamic changes of fibroblast growth factor 10 (FGF10),neutrophil/lymphocyte ratio (NLR),and C-reactive protein (CRP)/albumin (ALB) in patients with urinary tract infection after prostatectomy for benign prostatic hyperplasia (BPH). 【Methods】 A total of 164 patients with BPH admitted to our hospital from January 2018 to March 2021 were selected,all of whom underwent transurethral plasma bipolar resection of the prostate. They were divided into an infected group (n=33) and an uninfected group (n=131) based on whether urinary tract infection occurred after the surgery. Compare the baseline data of two groups,FGF10,NLR,CRP/ALB before and after surgery,analyze the influencing factors of urinary tract infection after BPH surgery,and evaluate the diagnostic value of FGF10,NLR,CRP/ALB for urinary tract infection after BPH surgery. 【Results】There were significant differences between the two groups in terms of age,operation time,proportion of prophylactic use of antibiotics before operation,and proportion of catheterization due to urinary retention before operation (P<0.05). The FGF10,NLR,CRP/ALB levels in both groups showed a trend of first increasing and then decreasing on the 1st,3rd,and 5th postoperative days,and both reached their peak on the 3rd postoperative day (P<0.05); The FGF10,NLR,CRP/ALB levels in the infected group were higher than those in the non infected group at 1 day,3 days,5 days after surgery (P<0.05). Multivariate logistic regression analysis showed that age,operation time,preoperative prophylactic use of antibiotics,preoperative catheterization due to urinary retention,and FGF10,NLR,CRP/ALB 3 days after operation were the important influencing factors for urinary tract infection after BPH (P<0.05). ROC curve analysis showed that the area under the curve of FGF10,NLR,CRP/ALB combined diagnosis of postoperative urinary tract infection in BPH at 3 days after surgery was 0.913,significantly better than a single indicator (P<0.05). The FGF10,NLR,CRP/ALB levels in patients with Gram negative bacteria were significantly higher than those with Gram positive bacteria (P<0.05). 【Conclusion】Patients with urinary tract infections after BPH surgery have elevated levels of FGF10,NLR,and CRP/ALB. Dynamic combined monitoring of these three factors can provide reference for clinical diagnosis and treatment,as well as differentiation of pathogenic bacteria types.
2023, Vol. 40 
