糖尿病肾病患者中性粒细胞与淋巴细胞比值与尿白蛋白排泄率的相关性

doi:10.3969/j.issn.1671-7171.2023.02.028

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摘要【目的】探讨中性粒细胞与淋巴细胞比值(NLR)与糖尿病肾病(DN)患者尿白蛋白排泄率(UAER)的相关性。【方法】收集就诊于两院明确诊断为DN的150例患者的临床资料,根据患者UAER水平(中位数)将患者分为高UAER组(UAER≥582.07 μg/min,n=76)及低UAER组(UAER<582.07 μg/min,n=74),比较两组患者NLR的差异,分析NLR与UAER的相关性。【结果】与低UAER组比较,高UAER组患者外周血NLR水平显著升高[(2.51±0.84)% vs(1.76±0.65)%,P<0.01],血肌酐(Scr)、尿素氮(BUN)均显著增高,但肾小球滤过率(eGFR)显著下降(P<0.05);UAER与NLR(r=0.724,P<0.01)、Scr(r=0.428,P=0.024)及BUN(r=0.502,P=0.037)为正相关,与eGFR(r=-0.364,P<0.01)呈负相关;二元Logistic回归分析发现,NLR与DN患者高UAER有相关性,其优势比(OR)(95%CI)为2.06(1.93~4.59)(P<0.01)。【结论】NLR与DN患者UAER密切相关,可作为预测DN患者出现蛋白尿的重要指标。

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	任莉
	王小艳

关键词 ：糖尿病肾病, 中性白细胞, 淋巴细胞, 白蛋白尿

Abstract：【Objective】To investigate the relationship between neutrophil-lymphocyte ratio (NLR) and urinary albumin excretion rate (UAER) in diabetic nephropathy (DN) patients. 【Methods】The clinical data of 150 DN patients diagnosed in Department of Nephrology in two hospitals were retrospectively analyzed. Patients were divided into the high UAER group (UAER≥582.07 μg/min,n=76) and the low UAER group (UAER<582.07 μg/min,n=74) according to the level of UAER,thus the differences of NLR in two groups were analyzed. 【Results】Compared to the low UAER group,the level of NLR was significantly increased in the high UAER group [(2.51±0.84) % vs (1.76±0.65) %,P<0.01]. In addition,the levels of Cr,BUN in the high UAER group significantly increased,however,eGFR decreased significantly. UAER had a positive correlation with NLR (r=0.724,P<0.01),Scr (r=0.428,P=0.024) and BUN (r=0.502,P=0.037) ,while it was negatively correlated with eGFR (r=-0.364,P<0.01).Binary logistic regression analysis showed that high NLR was associated with high UAER in DN patients,whose odds ratio (OR)(95%CI) was 2.06 (1.93~4.59) (P<0.01). 【Conclusion】NLR was closely related to UAER in DN patients,and this might be used as an indicator to predict urinary albumin in patients with DN.

Key words： Diabetic Nephropathies Neutrophils Lymphocytes Albuminuria

收稿日期: 2022-04-13

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R587.24

通讯作者: *E-mail:634246510@qq.com

引用本文:

任莉, 王小艳. 糖尿病肾病患者中性粒细胞与淋巴细胞比值与尿白蛋白排泄率的相关性[J]. 医学临床研究, 2023, 40(2): 258-260.
REN Li, WANG Xiao-yan. To Analyze the Relationship between Neutrophil-lymphocyte Ratio and Urinary Albumin Excretion Rate in Diabetic Nephropathy Patients. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 258-260.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.02.028 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I2/258