血沉、CRP、大便白细胞计数与溃疡性结肠炎患者发生SIBO的相关性及其对疾病分期的评估价值

doi:10.3969/j.issn.1671-7171.2023.04.009

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1138 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要【目的】探讨血沉(ESR)、C反应蛋白(CRP)、大便白细胞计数与溃疡性结肠炎(UC)患者发生小肠细菌过度生长(SIBO)的相关性及其对疾病分期的评估价值。【方法】选取2019年6月至2021年8月本院收治的154例UC患者,根据Southerland疾病活动指数(DAI)将其分为缓解期组、轻度活动组、中度活动组、重度活动组,通过乳果糖氢呼气试验(LHBT)分析SIBO发生情况。比较不同疾病分期患者血沉(ESR)、C反应蛋白(CRP)及大便白细胞计数(白细胞计数)及肠道黏膜屏障功能指标[二胺氧化酶(DAO)、细菌内毒素(LPS)、D-乳酸]水平,分析入院时ESR、CRP、大便白细胞计数与DAI评分、SIBO情况及肠道屏障功能的相关性。【结果】四组入院时ESR、CRP、大便白细胞计数、DAI评分比较,重度活动组＞中度活动组＞轻度活动组＞缓解期组,差异有统计学意义(P<0.05)。四组患者入院时DAO、LPS比较,重度活动组＞中度活动组＞轻度活动组＞缓解期组,差异有统计学意义(P<0.05);四组患者入院时D-乳酸水平比较,差异无统计学意义(P>0.05)。SIBO阳性组入院时ESR、CRP、大便白细胞计数水平高于SIBO阴性组,差异有统计学意义(P<0.05)。入院时ESR、CRP、大便白细胞计数与SDAI评分、LPS、DAO及SIBO呈正相关(P<0.05)。【结论】ESR、CRP、大便白细胞计数与UC患者病情分期及与发生SIBO具有显著相关性,可辅助临床早期诊断SIBO发生情况,为评估疾病分期提供参考。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	杜鑫
	杨永俊
	吴振伟

关键词 ：结肠炎,溃疡性, 血沉, C反应蛋白质, 白细胞计数, 小肠/微生物学

Abstract：【Objective】 To investigate the relationship of erythrocyte sedimentation rate (ESR),C-reactive protein (CRP) and fecal white blood cell count (WBC) with small intestinal bacterial overgrowth (SIBO) in patients with ulcerative colitis (UC) for evaluating the value of disease staging prediction. 【Methods】 A total of 154 patients with UC from June 2019 to August 2021 in our hospital were selected as the research subjects. Patients were divided into the remission group,the mild activity group,the moderate activity group,and the severe activity group according to the Southerland Disease Activity Index (DAI). The incidence of SIBO was determined by lactulose hydrogen breath test (LHBT). The erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),fecal white blood cell count (WBC) and intestinal mucosal barrier function indexes [diamine oxidase (DAO ) bacterial endotoxin (LPS),D-lactic acid] levels were measured. The correlation of ESR,CRP,fecal white blood cell count with DAI score,SIBO status and intestinal barrier function at admission was analyzed. 【Results】 The comparison of ESR,CRP,fecal white blood cell count,and DAI scores at admission among the four groups showed the order of the severe activity group>the moderate activity group > the light activity group > the remission group,which were statistically significant difference (P<0.05). The comparison of DAO and LPS among the four groups of patients at admission showed that the severe activity group>the moderate activity group>the mild activity group>the remission group,with a statistically significant difference (P<0.05). There was no statistically significant difference in D-lactate levels among the four groups of patients at admission (P>0.05). The levels of ESR,CRP,and fecal white blood cell count in the SIBO positive groups were higher than those in the SIBO negative groups at admission,with statistical significance (P<0.05). ESR,CRP,fecal white blood cell count at admission were positively correlated with SDAI score,LPS,DAO,and SIBO (P<0.05). 【Conclusion】 The levels of ESR,CRP,and fecal white blood cell count are significantly correlated with the stage of UC patients and the occurrence of SIBO,which can assist in early clinical diagnosis of SIBO and provide reference for evaluating disease stage.

Key words： Colitis,Ulcerative Blood Sedimentation C-Reactive Protein Leukocyte Count Intestine,Small/MI

收稿日期: 2022-07-23

中图分类号:

R574.62

引用本文:

杜鑫, 杨永俊, 吴振伟. 血沉、CRP、大便白细胞计数与溃疡性结肠炎患者发生SIBO的相关性及其对疾病分期的评估价值[J]. 医学临床研究, 2023, 40(4): 511-514.
DU Xin, YANG Yong-jun, WU Zhen-wei. Correlation of Erythrocyte Sedimentation Rate,CRP and Fecal WBC with Small Intestinal Bacterial Overgrowth in Patients with Ulcerative Colitis. JOURNAL OF CLINICAL RESEARCH, 2023, 40(4): 511-514.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.04.009 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I4/511

[1] 尹令迪,郑雪洁,宋丹丹,等.基于网络药理学和分子对接探究葛根调控溃疡性结肠炎的分子机制[J].现代药物与临床,2022,37(3):474-482.
[2] 刘治宏,崔立红.溃疡性结肠炎与小肠细菌过度生长关系探讨[J].胃肠病学和肝病学杂志,2018,27(5):497-501.
[3] 张予青,宋蕾,徐慧玲.葛根芩连汤加味对溃疡性结肠炎患者营养状况、T淋巴细胞亚群、CRP及ESR的影响[J].中医药信息,2022,39(3):64-68.
[4] MACK D R,SAUL B,BOYLE B,et al.Analysis of using the total white blood cell count to define severe new-onset ulcerative colitis in children[J].J Pediatr Gastroenterol Nutr,2020,71(3):354-360.
[5] 中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见(2012年·广州)[J].中华内科杂志,2012,32(10):818-831.
[6] 何碧瑜,王佩茹,杨维忠,等.溃疡性结肠炎患者炎性因子水平、肠道菌群分布及发病相关因素分析[J].华南预防医学,2022,48(2):178-181.
[7] 乔炜,张永欢,李娜,等.溃疡性结肠炎组织中suPAR表达情况与炎性因子和肠道菌群的相关性[J].临床医学研究与实践,2022,7(4):106-109.
[8] 杨聪,邱燕飞.血清C-反应蛋白、降钙素原、淀粉样蛋白A联合检测在溃疡性结肠炎诊断中的应用价值分析[J].吉林医学,2022,43(5):1331-1333.
[9] 苏淑伶,苏龙,郑丽丽,等.HIF-1α、COX-2、CRP及ESR在溃疡性结肠炎患者外周血及黏膜组织中的表达及临床意义[J].临床和实验医学杂志,2022,21(4):415-419.
[10] 王磊,罗瑞娟,李娜,等.优化溃结方对溃疡性结肠炎临床疗效及血清炎症因子CRP、TNF-α的影响[J].中华中医药学刊,2022,40(4):89-92.
[11] 王剑.美沙拉嗪在溃疡性结肠炎治疗中对患者ESR、PLT、D-D水平的影响分析[J].中国现代药物应用,2019,13(22):175-176.
[12] 王慧.降钙素原、C反应蛋白、白细胞计数联合检测在鉴别不同类型小儿肠炎中的价值分析[J].中国基层医药,2021,28(6):865-869.
[13] KANDAVEL P,EDER S J,NEWMAN N E,et al.Mean corpuscular volume to white blood cell ratio for thiopurine monitoring in pediatric inflammatory bowel disease[J].J Pediatr Gastroenterol Nutr,2019,69(1):88-94.
[14] 杨春春,王竞,文欢,等.溃疡性结肠炎患者小肠细菌过度生长情况分析及意义[J].重庆医学,2021,50(2):207-210.