Abstract：【Objective】To investigate the value of helper T cell 22 (Th22) and serum interleukin-22(IL-22) levels in predicting the severity of lupus nephritis (LN). 【Methods】Sixty two patients with systemic lupus erythematosus (SLE) were admitted to our hospital. The patients with more than 8 glomeruli in renal biopsy sections were included in the LN group (n=28),and the rest of patients were included in the SLE group (n=34). Meanwhile,30 healthy volunteers in the same period were selected as the control group. LN patients with SLE-DAI score ≥ 10 were set as active group (n=11),and those with SLE-DAI score<10 were set as stable group (n=17). The renal function indexes (BUN,Scr,GFR) and the levels of helper T cell 1 (Th1),Th22,IL-22 in each group were compared. The value of Th22 and IL-22 levels in predicting the severity of LN patients was analyzed. Spearman rank correlation analysis was used to reveal the correlation of levels of Th22 and IL-22 with SLE-DAI scores of LN patients. 【Results】The levels of Scr,BUN,Th22,and IL-22 in the control group were significantly lower than those in the LN group and the SLE group,while the levels of GFR were higher than those in the two groups (P<0.05). The levels of Scr and BUN in the SLE group were significantly lower than those in the LN group (P<0.05). There was no significant difference in the levels of Th22,IL-22 and GFR between the LN group and the SLE group (P>0.05). There were no significant differences in Th1 levels among the three groups (P>0.05). There were no significant differences in the levels of SCR,GFR,BUN and Th1 between the active group and the stable group (P>0.05). Th22 and IL-22 levels in the active group were significantly higher than those in the stable group (P<0.05). According to ROC analysis,the best cutoff values of Th22 and IL-22 levels for predicting the severity of LN patients were Th22≥7.180% and IL-22≥64.955 pg/mL,respectively (both P<0.05). Correlation analysis showed that Th22 and IL-22 levels were positively correlated with SLE-DAI scores of LN patients (P<0.05). 【Conclusion】The levels of Th22 and IL-22 in peripheral blood of SLE and LN patients were significantly higher than those of normal people,and there were significant differences among LN patients with different disease severity,which was significantly positively correlated with the disease activity of LN patients.
高青青, 杲和艳, 赵成群, 李晓龙. Th22细胞及血清IL-22水平预测狼疮性肾炎患者病情程度的价值[J]. 医学临床研究, 2022, 39(12): 1806-1809.
GAO Qing-qing, GAO He-yan, ZHAO Cheng-qun, et al. Value of Th22 Cells and Serum IL-22 Level in Predicting the Severity of Lupus Nephritis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(12): 1806-1809.
[1] LIU B X,LU F,LIN J,et al. Correlations of serum beta 2-microglobulin level with disease activity and renal involvement in patients with systemic lupus erythematosus[J].J Laborat Med,2021,45(1):13-18. [2] ZHANG T,LIU X,ZHAO Y,et al. excessive i1 15 promotes cytotoxic cd4 cd28 t ce11 mediated rena1 injury in 1upus nephritis[J].Immun Ageing,2022,19(1):50-62. [3] MAJUMDER S,SINGH P,CHATTERJEE R,et al. Elevated urinary IL-36γ in patients with active lupus nephritis and response to treatment[J].Lupus,2021,30(6):921-925. [4] JIAO Q,QIAN Q,LIU C,et al. T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T-cell costimulator[J].Br J Dermatol,2020,182(3):648-657. [5] 中华医学会风湿病学分会. 系统性红斑狼疮诊断及治疗指南中华医学会风湿病学分会[J].中华风湿病学杂志,2010,14(5):342-346. [6] LIGTENBERG G,ARENDS S,STEGEMAN C A,et al. Predictors of renal flares and long-term renal outcome in patients with lupus nephritis:results from daily clinical practice[J].Clin Exp Rheumatol,2022,40(1):33-38. [7] 顾丽萍,杨贵丽,陈幼发,等. Th22细胞及其功能分子IL-22在狼疮性肾炎中的作用研究[J].中国免疫学杂志,2017,33(5):755-758. [8] YANG X,WENG Q,HU L,et al. Increased interleukin-22 levels in lupus nephritis and its association with disease severity:a study in both patients and lupus-like mice model[J].Clin Exp Rheumatol,2019,37(3):400-407. [9] EL-GAZZAR I I,BAHGAT D,KHATEEB E E . IL22 in Egyptian SLE patients,could it reflect disease activity,skin or renal involvement or is it only an expensive ESR?[J].Egypt Rheumatol,2017,39(1):13-18. [10] 周璇,寇沛. 血清Chemerin及IL-22水平在狼疮性肾炎中的表达及其与疾病活动性的相关性[J].浙江临床医学,2016,18(3):466-468. [11] 赵令,马宁,刘涛,等. 系统性红斑狼疮患者外周血辅助性T细胞亚型和细胞因子的检测及其临床意义[J].吉林大学学报(医学版),2014,40(2):399-403.
2022, Vol. 39 
