Abstract：【Objective】To investigate the value of combined detection of serum lipoprotein-associated phospholipese A2 (Lp-PLA2) and cardiac troponin T (cTnT) in predicting the occurrence of MACE (Major adverse cardiovascular events) in elderly patients with hip fractures during perioperative period. 【Methods】A total of 1,267 elderly patients with hip fractures who underwent surgical treatment in our hospital between January 2015 and June 2021 were selected for prospective analysis. All patients underwent internal fixation or artificial hip replacement within 2 to 5 d after admission. There were 84 patients who developed MACE within 30 days after surgery were included in the MACE group,while 127 patients who were randomly (by using the random number table method) selected from no MACE patients were considered as the control group. The general data,preoperative examination results,perioperative indicators and levels of serum Lp-PLA2 and cTnT were collected and compared between the two groups. Receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to analyze the predictive value of serum Lp-PLA2 and cTnT levels in predicting perioperative MACE. 【Results】The average age,proportion of coronary heart disease and complication with other diseases in the MACE group were significantly higher than those in control group (P<0.05). The levels of serum Lp-PLA2 and cTnT at 1 d,3 d and 7 d after surgery in the two groups significantly increased if compared to those at 1 d before surgery (P<0.05). In addition,the levels of serum Lp-PLA2 and cTnT in the MACE group at 1 d,3 d and 7 d after surgery were higher than those in control group (P<0.05). ROC curve analysis results showed that the AUC values of serum Lp-PLA2,cTnT and the combination of both detections at 1 d after surgery in predicting perioperative MACE in elderly patients with hip fractures were 0.665,0.703 and 0.755,respectively; The AUC values of serum Lp-PLA2,cTnT and combination of the two at 3 d after surgery were 0.765,0.792 and 0.853,and their AUC values at 7 d after surgery were 0.825,0.852 and 0.932,respectively. 【Conclusion】The levels of serum Lp-PLA2 and cTnT in elderly patients with hip fractures are significantly increased after surgery. The combined detection of the two has a good reference value for predicting the occurrence of perioperative MACE.
梁立卓, 芦斌. 血清Lp-PLA2、cTnT联合检测对老年髋部骨折患者围术期发生MACE的预测价值[J]. 医学临床研究, 2022, 39(11): 1608-1611.
LIANG Li-zhuo, LU Bin. Clinical Value of Combined Detection of Serum Lp-PLA2 and cTnT in Predicting Occurrence of Perioperative MACE in Elderly Patients with Hip Fractures. JOURNAL OF CLINICAL RESEARCH, 2022, 39(11): 1608-1611.
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2022, Vol. 39 
