视黄醇脱氢酶10对经TACE治疗的肝细胞肝癌患者预后的诊断价值

doi:10.3969/j.issn.1671-7171.2022.10.025

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摘要【目的】探讨外周血单个核细胞中视黄醇脱氢酶10(RDH10)对经肝动脉化疗栓塞术(TACE)治疗的肝细胞肝癌(HCC)患者预后的诊断价值。【方法】本院就诊的202例HCC患者,根据其3年生存预后将其分为生存组(n=125)和死亡组(n=77)。采集患者TACE前(T₁)、TACE后3 d(T₂)和TACE后7 d(T₃)的空腹静脉血,用Ficoll密度梯度离心法分离外周血中单个核细胞,用蛋白质免疫印迹法检测单个核细胞中RDH10表达水平并进行比较。【结果】生存组和死亡组患者RDH10表达水平均随时间延长呈降低趋势,生存组的T₂、T₃时RDH10表达水平均低于死亡组(P<0.05)。T₃时的RDH10诊断HCC患者预后的效能高于T₁和T₂时的RDH10,且差异均有统计学意义(P<0.05)。COX回归分析结果显示,索拉非尼、利卡汀是HCC患者预后的独立保护因素(P<0.05),肿瘤直径、肿瘤分期和T₃时的RDH10均是HCC患者预后的独立危险因素(P<0.05)。【结论】TACE后7 d外周血单个核细胞中RDH10表达水平与HCC患者预后有关,其对TACE治疗预后有一定的诊断价值。

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	王杰
	张翠翠

关键词 ：癌,肝细胞, 化学栓塞,治疗性, 预后

Abstract：【Objective】To investigate the value of retinol dehydrogenase 10 (RDH10) in peripheral blood mononuclear cells for the prognosis of hepatocellular carcinoma (HCC) after transhepatic arterial chemoembolization (TACE). 【Methods】A total of 202 HCC patients who were treated in our hospital were divided into the survival group (n=125) and the death group (n=77) according to the 3-year survival prognosis. The fasting venous blood was drawn from patients before TACE (T₁), 3 days after TACE (T₂) and 7 days after TACE (T₃). Ficoll density gradient centrifugation was used to isolate mononuclear cells from peripheral blood. Western blot was used to detect the expression level of RDH10 in mononuclear cells. 【Results】The expression levels of RDH10 in both survival and death groups decreased with time progression. The expression levels of RDH10 at T₂ and T₃ in the survival group were lower than those in the death group (P<0.05). The efficacy of RDH10 at T₃ for predictive prognosis of HCC patients was higher than those of RDH10 at T₁ and RDH10 at T₂; And the differences were statistically significant (P<0.05). COX regression analysis showed that sorafenib and licartin were independent protective factors for the prognosis of HCC patients (P<0.05). The tumor diameter, tumor stage, and RDH10 (T₃) were all independent risk factors for the prognosis of HCC patients (P<0.05). 【Conclusion】The expression level of RDH10 in peripheral blood mononuclear cells on the 7th day after TACE is related to the prognosis of HCC patients, which has certain diagnostic value for the prognosis of TACE treatment.

Key words： Carcinoma, Hepatocellular Chemoembolization, Therapeutic Prognosis

收稿日期: 2022-03-07

中图分类号:

R735.7

引用本文:

王杰, 张翠翠. 视黄醇脱氢酶10对经TACE治疗的肝细胞肝癌患者预后的诊断价值[J]. 医学临床研究, 2022, 39(10): 1531-1534.
WANG Jie, ZHANG Cui-cui. Value of Retinol Dehydrogenase 10 in Prognosis of Hepatocellular Carcinoma after TACE Treatment. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1531-1534.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.10.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I10/1531

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