彩色多普勒超声检查联合血清gal-3、sST2水平在高血压左室肥厚伴左心衰竭中的诊断价值

doi:10.3969/j.issn.1671-7171.2022.10.018

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摘要【目的】探讨彩色多普勒超声检查联合血清半乳糖凝集素-3(gal-3)、可溶性生长刺激表达基因2蛋白(sST2)水平在高血压左室肥厚伴左心衰竭中的诊断价值。【方法】选取2018年1月至2021年12月在本院诊治的96例高血压左室肥厚伴左心衰竭患者(观察组),另外,选取同期在本院体检且无心血管疾病的96例健康志愿者(对照组)。两组均行彩色多普勒超声检查联合血清gal-3、sST2水平检测,比较两组及观察组不同心功能分级患者彩色多普勒超声指标[左室短轴缩短率(LVFS)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左房内径(LAD)、室间隔厚度(IVST)及左室后壁厚度(LVPWT)、左室射血分数(LVEF)、左室Tei指数及舒张早期、舒张晚期最大充盈速度比值(E/A)]及血清gal-3、sST2水平,采用Pearson分析彩色多普勒超声指标及血清gal-3、sST2水平与心功能分级的相关性。【结果】观察组LVESD、LVEDD、LAD、IVST、LVPWT、左室Tei指数及血清gal-3、sST2水平均高于对照组,LVFS、LVEF、E/A均低于对照组(P<0.05)。观察组心功能Ⅳ级患者LVESD、LVEDD、LAD、IVST、LVPWT、左室Tei指数及血清gal-3、sST2水平均大于心功能Ⅱ级、Ⅲ级患者,LVFS、LVEF、E/A均小于心功能Ⅱ级、Ⅲ级患者(P<0.05);心功能Ⅲ级患者LVESD、LVEDD、LAD、IVST、LVPWT、左室Tei指数及血清gal-3、sST2水平均大于心功能Ⅱ级患者,LVFS、LVEF、E/A均小于心功能Ⅱ级患者(P<0.05)。Pearson相关性分析显示:左室Tei指数及血清gal-3、sST2水平与心功能分级呈正相关(P<0.05);E/A、LVEF、LVFS与心功能分级呈负相关(P<0.05);LVESD、LVEDD、LAD、IVST、LVPWT与心功能分级无相关性(P>0.05)。【结论】彩色多普勒超声检查联合血清gal-3、sST2水平对高血压左室肥厚伴左心衰竭具有较高的诊断价值,可应用于临床诊断高血压左室肥厚伴左心衰竭。

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	校王莉

关键词 ：高血压/并发症, 肥大,左心室/诊断, 心力衰竭/诊断, 超声检查, 多普勒, 彩色

Abstract：【Objective】To study the application value of color ultrasound combined with serum galactose agglutinin-3(gal-3) and soluble growth stimulating expression gene 2 protein(sST2) in the diagnosis of hypertensive left ventricular hypertrophy with left heart failure. 【Methods】96 hypertensive left ventricular hypertrophy with left heart failure patients diagnosed in our hospital from January 2018 to December 2021 were included in the study group, and 96 patients without cardiovascular disease who underwent physical examination in our hospital during the same period were included in the control group.Color ultrasound combined with serum gal-3 and sST2 were performed in both groups. Color ultrasound indexes and serum gal-3 and sST2 levels of patients with different cardiac function grades were compared between the two groups and the study group. The color ultrasound indexes and serum gal-3 and sST2 levels of patients with different cardiac function grades in the study group were compared, and the correlation between color ultrasound indexes, serum gal-3 and sST2 levels and cardiac function grades was analyzed by Pearson correlation.【Results】LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels in the study group were higher than those in the control group, LVFS, LVEF and E/A were lower than those in the control group (P<0.05). In the study group, LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels of patients with grade Ⅳ cardiac function were higher than those of patients with grade Ⅱ and Ⅲ cardiac function, LVFS, LVEF and E/A were lower than those of patients with grade Ⅱ and Ⅲ cardiac function (P<0.05). LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels were higher in grade Ⅲ patients than in grade Ⅱ patients, LVFS, LVEF and E/A were lower than in grade Ⅱ patients (P<0.05). Pearson correlation analysis showed that serum gal-3 and sST2 levels of LEFT ventricular Tei index were positively correlated with cardiac function grading, while E/A, LVEF, LVFS were negatively correlated with cardiac function grading (P<0.05). There was no correlation between LVESD, LVEDD, LAD, IVST, LVPWT and cardiac function grading (P>0.05). 【Conclusion】Color ultrasound combined with serum gal-3 and sST2 has high diagnostic value for hypertensive left ventricular hypertrophy with left heart failure, and can be applied to clinical diagnosis of hypertensive left ventricular hypertrophy with left heart failure.

Key words： Hypertension/CO Hypertrophy, Left Ventricular/DI Heart Failure/DI Ultrasonography, Doppler, Color

收稿日期: 2022-03-03

中图分类号:

R544.1

通讯作者: *E-mail:xwl063888@163.com

引用本文:

贾贝, 校王莉. 彩色多普勒超声检查联合血清gal-3、sST2水平在高血压左室肥厚伴左心衰竭中的诊断价值[J]. 医学临床研究, 2022, 39(10): 1505-1508.
JIA Bei, XIAO Wang-li. Application Value of Color Ultrasound Combined with Serum gal-3 and sST2 in the Diagnosis of Hypertensive Left Ventricular Hypertrophy with Left Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1505-1508.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.10.018 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I10/1505

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