Abstract：[Objective]To explore the efficacy and adverse reaction of mycophenolate mofetil (MMF) com-bined with tacrolimus(TAC) for the treatment of steroid-resistant nephrotic syndrome(SRNS) .[Methods]To-tally 74 SRNS patients were collected .Pathological types included 32 cases of minimal lesion(MCD) ,22 cases of local segmental glomerulosclerosis (FSGS ) and 20 cases of diffuse mesangial proliferation (DM P ) .All pa-tients were treated with MMF 1g/day and prednisolone 50mg(alternate day) for 6 months(first-step treat-ment) .For the patients without clinical remission after the first-step treatment automatically received the sec-ond-step treatment i .e .the withdrawal of steroids and then MMF 1g/day combined with TAC 3mg/day for 6 months .The efficacy of different therapy methods ,pathological types and adverse reaction were observed .[Results]In 74 SRNS patients receiving the first-step treatment ,24 patients(32 .4% ) got complete remission , and 4 patients(5 .4% ) got partial remission ,and the other 46 patients did not get clinical remission and then stopped steroids and received the second treatment .Among these 46 patients ,22 patients(47 .8% ) got com-plete remission and 4 patients(8 .7% ) got partial remission .There was significant difference in the remission rate among different pathological types ( P <0 .05) .The remission rate of MCD was the highest and that of FSGS was the lowest .No obvious adverse reaction was found in all patients during the therapy .[Conclusion]MMF combined with TAC for the treatment of SRNS has satisfactory effect ,so it is worthy of clinical promo-tion .
2014, Vol. 31 
