Abstract：【Objective】 To investigate the efficacy of tacrolimus combined with glucocorticoid in the treatment of nephrotic syndrome and the effect on the inflammatory factors. 【Methods】Eighty-six patients with nephrotic syndrome were randomly divided into the experimental group and the control group with 43 cases in each group. Both groups were treated with glucocorticoid, while the experimental group was additionally treated with tacrolimus. The blood lipids [triglyceride (TG), serum total cholesterol (TC), low- density lipoprotein (LDLC), high-density lipoprotein (HDLC)], inflammatory factors [interleukin -1 (IL-1), interleukin -6 (IL-6), tumor necrosis factor alpha (TNF-α)], renal function [blood urea nitrogen (BUN), serum creatinine (SCr), 24h urine protein quantitation] and adverse drug reactions were observed before and after treatment. 【Results】Before treatment, all showed no significant differences between the two groups (P>0.05); After treatment, TG, TC, LDLC, IL-1, IL-6, TNF-α, BUN, SCr and 24h urine protein quantitation decreased significantly while HDLC increased significantly; After treatment, TG, TC, LDLC, IL-1, IL-6, TNF-α, BUN, SCr, 24h urinary protein in the experimental group were significantly lower than those in the control group, HDLC increased significantly, and the difference was significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups (P>0.05).【Conclusion】 Tacrolimus combined with glucocorticoid in the treatment of nephrotic syndrome can significantly reduce the expression of inflammatory factors and improve the renal function of patients by effectively regulating the blood lipid levels.
唐杰;. 他克莫司联合糖皮质激素治疗肾病综合征的疗效及对炎症因子的影响[J]. 医学临床研究, 2017, 34(4): 685-687.
TANG Jie. Efficacy of Tacrolimus Combined with Glucocorticoid in Patients with Nephrotic Syndrome and its Effect on Inflammatory Factors. JOURNAL OF CLINICAL RESEARCH, 2017, 34(4): 685-687.
2017, Vol. 34 
