Clinical Effect of Xingpi Yanger Granules Combined with Bifidobacterium Lactobacillus Triple Viable Capsules and Lysine Glucozinc Granules in the Treatment of Infantile Anorexia
WANG Ping, XUE Lei
Department of Pediatrics,Xi'an Gaoxin Hospital,Xi'an Shaanxi 710075
Abstract:【Objective】To investigate the clinical effect of Xingpi Yanger granules combined with bifid triple viable capsules and lysine glucozinc granules in the treatment of anorexia. 【Methods】A total of 112 children with anorexia who were admitted to Xi'an Gaoxin Hospital from October 2019 to June 2020 were selected and divided into the observation group and the control group by random number table method, with 56 cases in each group. The control group was given bifidobacterium lactobacillus triple viable capsules and lysine glucozinc granules, and the observation group was given Xingpi Yanger Granules on the basis of the control group. The curative effect and the occurrence of adverse reactions were compared between the two groups, and the levels of serum zinc (Zn), appetite regulating factors [motilin (MTL), substance P (SP)], body weight and height before and after treatment were compared between the two groups. 【Results】The total effective rate in the observation group was 96.43% (54/56), which was higher than 82.14% (46/54) in the control group, and the difference was statistically significant (P<0.05). After treatment, the serum levels of Zn, MTL and SP in the two groups were higher than those before treatment; and the observation group was higher than the control group. The differences were statistically significant (P<0.05). There was no significant difference in height between the two groups before treatment (P>0.05). However, the weight of the two groups of children was higher than that before treatment. The weight in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). There were no adverse reactions in the two groups during the treatment, and the children were well tolerated. 【Conclusion】Xingpi Yanger granules combined with bifidobacterium lactobacillus triple viable capsules and lysine glucozinc granules have very good effect in the treatment of children with anorexia, which can effectively regulate the levels of serum Zn and appetite regulating factors, and play an important role in promoting growth and development.
[1] 李司鹏,蓝陈福.布拉酵母菌联合葡萄糖酸锌治疗厌食症的疗效及其对患儿微量元素与脑肠肽水平的影响[J].儿科药学杂志,2017,23(12):15-17.
[2] KANG H J,JEONG M K,PARK S J,et al.Efficacy and safety of Yukgunja-Tang for treating anorexia in patients with cancer:The protocol for a pilot,randomized,controlled trial[J].Medicine (Baltimore),2019,98(40):e16950.
[3] 杨丽萍.功能性消化不良病儿应用双歧杆菌三联活菌胶囊联合多潘立酮的胃动力学指标分析[J].安徽医药,2019,23(5):1016-1020.
[4] 杨丽梅.小儿厌食症相关因素分析[J].新疆医学,2017,47(5):538-539.
[5] 李琛,刘秀芬,刘志明,等.醒脾养儿颗粒联合复方嗜酸乳杆菌对IBS患儿T淋巴细胞亚群,脑肠肽及炎症因子的影响[J].现代消化及介入诊疗,2020,25(5):87-90.
[6] 刘汉玉,何红霞.参苓白术散联合布拉氏酵母菌治疗小儿厌食症的疗效及对食欲调节因子的影响[J].现代中西医结合杂志,2017,26(14):1549-1552.
[7] 程玉莲.醒脾养儿颗粒治疗小儿厌食症的效果观察[J].北方药学,2019,16(7):76-77.[8] 张娴,李艳红,李燕,等.云南贫困少数民族地区婴幼儿微量元素锌,铁,铜与膳食营养的关系分析[J].昆明医科大学学报,2019,40(1):30-35.
[9] 周雄飞,郑君.补锌对儿童轮状病毒性胃肠炎血锌,免疫球蛋白,补体和炎症因子的影响[J].中国儿童保健杂志,2018,198(12):117-120.
[10] 王波,杨继国,任杰,等.酪蛋白肽电荷性质对其肽-锌螯合物的胃肠稳定性及吸收的影响[J].中国食品添加剂,2019,30(3):59-66.
[11] 潘慧,卢小蕴,吕小青.醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿功能性消化不良及其对血清炎症因子影响[J].浙江中西医结合杂志,2018,28(2):126-128.