终末期肾病合并房颤患者血液透析治疗后低分子肝素抗凝出血的危险因素分析

doi:10.3969/j.issn.1671-7171.2022.03.025

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摘要【目的】探讨终末期肾病(ESRD)合并房颤患者血液透析治疗后低分子肝素抗凝出血的危险因素。【方法】回顾性分析本院收治的500例ESRD合并房颤患者的临床资料,统计分析患者血液透析治疗后低分子肝素抗凝出血的发生情况,采用Logistic回归分析ESRD合并房颤患者血液透析治疗后低分子肝素抗凝出血的影响因素。【结果】ESRD合并房颤患者血液透析治疗后低分子肝素抗凝出血事件发生率为7.40%(37/500)。出血组与未出血组患者在年龄、饮酒史、合并消化道疾病、周透析时间、血小板计数、低钙血症、进食辛辣食物方面比较差异均有统计学意义(P<0.05)。Logistic多因素分析显示,合并消化道疾病、周透析时间、低钙血症是ESRD合并房颤患者血液透析治疗后低分子肝素抗凝出血的独立影响因素(P<0.05)。【结论】合并消化道疾病、周透析时间、低钙血症是ESRD合并房颤患者血液透析治疗后低分子肝素抗凝出血的危险因素。

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	赵辽辽
	常露元

关键词 ：血液透析滤过, 肾疾病/并发症, 心房颤动/并发症, 肝素,低分子量/治疗应用

Abstract：【Objective】To explore the risk factors of low molecular weight heparin anticoagulant bleeding in patients with end-stage renal disease (ESRD) with atrial fibrillation after hemodialysis treatment. 【Methods】A retrospective analysis of the clinical data of 400 ESRD patients with atrial fibrillation admitted to our hospital was performed. The incidence of low molecular weight heparin anticoagulant bleeding after hemodialysis in ESRD patients with atrial fibrillation was counted. Logistic regression analysis was used to analyze the multiple factors affecting low molecular weight heparin anticoagulant bleeding in patients with ESRD with atrial fibrillation after hemodialysis treatment. 【Results】The incidence of low-molecular-weight heparin anticoagulant bleeding events after hemodialysis in ESRD patients with atrial fibrillation was 7.40% (37/400). There were statistically significant differences between the bleeding group and the non-bleeding group in terms of age, drinking history, comorbid digestive tract disease, weekly dialysis time, platelet count, hypocalcemia, and spicy food eating habit(P<0.05). Logistic multivariate analysis showed that gastrointestinal diseases, weekly dialysis time, and hypocalcemia were independent influencing factors of low molecular weight heparin anticoagulant bleeding after hemodialysis in ESRD patients with atrial fibrillation (P<0.05). 【Conclusion】Gastrointestinal diseases, weekly dialysis time and hypocalcemia are risk factors for low-molecular-weight heparin anticoagulant bleeding in ESRD patients with atrial fibrillation after hemodialysis treatment.

Key words： Hemodiafiltration Kidney Diseases/CO Atrial Fibrillation/CO Heparin, Low-Molecular-Weight/TU

收稿日期: 2021-10-22

中图分类号:

R692

通讯作者: * E-mail:changluyuan123@163.com

引用本文:

赵辽辽, 常露元. 终末期肾病合并房颤患者血液透析治疗后低分子肝素抗凝出血的危险因素分析[J]. 医学临床研究, 2022, 39(3): 412-414.
ZHAO Liao-liao, CHANG Lu-yuan. Analysis of Risk Factors for Low Molecular Weight Heparin Anticoagulant Bleeding in End-stage Renal Disease Patients with Atrial Fibrillation after Hemodialysis. JOURNAL OF CLINICAL RESEARCH, 2022, 39(3): 412-414.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.03.025 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I3/412

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