Abstract：【Objective】To explore the changes of intestinal microecology and immune function in children before and after Helicobacter pylori (Hp) eradication treatment. 【Methods】The clinical data of 91 children with HP infection admitted to the hospital from September 2017 to March 2020 were retrospectively analyzed. All children were treated with a quadruple standardized radical cure for HP infection. The changes of intestinal microecology and immune function in children before and after eradication treatment were compared. Drug safety was evaluated. 【Results】After treatment, the proportion of Escherichia coli, Enterococcus, Clostridium, and Parabacteroides was higher than before treatment (P<0.05), The proportion of Pretotella, Bifidobacterium, Lactobacillus, Koala, Bacteroides was lower than before treatment (P<0.05). CD3+, CD4+ and CD4+/CD8+ levels after treatment were higher than those before treatment (P<0.05), while CD8+ level after treatment was lower than before treatment (P<0.05). The levels of IgA, IgM and IgG after treatment in children were higher than before treatment (P<0.05). The children had no obvious adverse reactions, and the safety was good during the treatment. 【Conclusion】The structure of the intestinal flora changes in children with Hp infection after eradication treatment, which can effectively improve their immune function.
吕荣芬, 胡君伟. 幽门螺杆菌根除治疗前后患儿肠道菌群及免疫功能变化情况分析[J]. 医学临床研究, 2021, 38(8): 1170-1172.
LYU Rong-fen, HU Jun-wei. Changes of Intestinal Microecology and Immune Function in Children before and after Helicobacter Pylori Eradication Treatment. JOURNAL OF CLINICAL RESEARCH, 2021, 38(8): 1170-1172.
2021, Vol. 38 
