急性感染性心内膜炎患者治疗过程中CRP/HGB、ESR、Gal-3动态变化情况分析

doi:10.3969/j.issn.1671-7171.2021.12.016

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摘要【目的】探讨急性感染性心内膜炎(AIE)患者治疗过程中C反应蛋白(CRP)与血红蛋白(HGB)比值(CRP/HGB)、血沉(ESR)、半乳糖凝集素-3(Gal-3)动态变化情况。【方法】选取本院收治的147例AIE患者,根据入院后1个月内生存情况将其分为死亡组(n=23)、生存组(n=124)。比较两组治疗前、治疗1周后、治疗2周后CRP/HGB、ESR、Gal-3、白细胞计数(WBC)、降钙素原(PCT)水平,采用Logistic回归方程分析预后的相关影响因素,采用受试者工作特征曲线(ROC)分析各指标预测预后价值。【结果】治疗1周、2周后,死亡组血清CRP/HGB、ESR、Gal-3、WBC、PCT水平与治疗前比较,差异无统计学意义(P>0.05);生存组上述指标均低于治疗前,死亡组高于生存组,差异有统计学意义(P<0.05)。Logistic回归方程分析显示,治疗1周、2周后CRP/HGB、ESR、Gal-3水平是影响患者预后的相关因素(P<0.05)。治疗2周后CRP/HGB、ESR、Gal-3预测预后的AUC分别为0.827、0.844、0.836(P<0.05),CRP/HGB+ESR+Gal-3预测预后的AUC为0.949(P<0.05)。【结论】治疗过程中监测CRP/HGB、ESR、Gal-3水平对评估AIE患者预后具有重要意义,可辅助临床预测患者预后转归。

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	王颖
	杨鲲
	何勇

关键词 ：感染/病因学, 心内膜炎/病因学, 急性病, C反应蛋白质, 血沉, 半乳糖凝集素 3

Abstract：【Objective】To investigate the dynamic changes of C-reactive protein (CRP) to hemoglobin (Hgb) ratio (CRP/Hgb), erythrocyte sedimentation rate (ESR) and galactose lectin-3 (Gal-3) in patients with acute infective endocarditis (AIE).【Methods】A total of 147 patients with AIE was selected. According to the survival within 1 month after admission, they were divided into death group (n=23) and survival group (n=124). The levels of CRP/HGB, ESR, Gal-3, white blood cell count (WBC) and procalcitonin (PCT) were compared between the two groups before treatment, 1 week after treatment and 2 weeks after treatment. The relevant influencing factors of prognosis were analyzed by logistic regression equation, and the working characteristic curve of subjects was used (ROC) the prognostic value of each index was analyzed. 【Results】 After 1 and 2 weeks of treatment, the levels of serum CRP/HGB, ESR, Gal-3, WBC and PCT in the death group were not significantly different from those before treatment (P>0.05); the above indexes in the survival group were lower than those before treatment, and the death group was higher than that in the survival group (P<0.05). Logistic regression equation analysis showed that the levels of CRP/HGB, ESR and Gal-3 after 1 and 2 weeks of treatment were related factors affecting the prognosis of patients (P<0.05). The AUCs of CRP/HGB, ESR and Gal-3 after 2 weeks of treatment were 0.827, 0.844 and 0.836 respectively (P<0.05), and the AUC of CRP/HGB+ESR+Gal-3 was 0.949 (P<0.05). 【Conclusion】 Monitoring the levels of CRP/HGB, ESR and Gal-3 during treatment is of great significance to evaluate the prognosis of AIE patients, and can assist in predicting the prognosis of AIE patients.

Key words： Infection/ET Endocarditis/ET Acute Disease C-Reactive Protein Blood Sedimentation Galectin 3

收稿日期: 2021-04-21

中图分类号:

R542.42

通讯作者: *E-mail:56155261@qq.com

引用本文:

王颖, 杨鲲, 何勇. 急性感染性心内膜炎患者治疗过程中CRP/HGB、ESR、Gal-3动态变化情况分析[J]. 医学临床研究, 2021, 38(12): 1815-1817.
WANG Ying, YANG Kun, HE Yong. Dynamic Changes of CRP/HGB, ESR and Gal-3 in Patients with Acute Infective Endocarditis during Treatment. JOURNAL OF CLINICAL RESEARCH, 2021, 38(12): 1815-1817.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2021.12.016 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2021/V38/I12/1815