极(超)低出生体质量早产儿支气管肺发育不良高危因素分析

doi:10.3969/j.issn.1671-7171.2020.06.003

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摘要【目的】探讨极(超)低出生体质量早产儿支气管肺发育不良(BPD)发生的危险因素。【方法】回顾性分析2017年1月至2019年12月本院NICU收治的139例极(超)低出生体质量早产儿的临床资料,根据出院时是否确诊为BPD,将其分为非BPD组(n=81)和BPD组(n=58)。比较两组早产儿在母亲年龄、绒毛膜羊膜炎,患儿性别、胎龄、出生体质量等方面的差异,并进行多因素logistic回归分析BPD发生的独立危险因素。【结果】 BPD组早产儿母亲绒毛膜羊膜炎、辅助受孕所占比例高于非BPD组,差异有统计学意义(P<0.05)。BPD组早产儿住院时间高于非BPD组,男性、有创呼吸机使用、新生儿呼吸窘迫综合征(NRDS)、肺表面活性物质(PS)、新生儿肺炎、咽拭子UU检测阳性所占比例均高于非BPD组,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,极(超)低出生体质量早产儿发生BPD的独立高危因素为胎龄、NRDS(P<0.05)。【结论】绒毛膜羊膜炎、出生体质量、胎龄、NRDS、使用有创呼吸机、咽拭子UU检测阳性可导致极(超)低出生体质量儿BPD的发生,其中胎龄、NRDS为独立危险因素。

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关键词 ：婴儿,极低出生体重, 婴儿,超低出生体重, 支气管肺发育不良

Abstract：【Objective】To analyze the risk factors of bronchopulmonary dysplasia (BPD) in very (extremely) low birth weight premature infants. 【Methods】A total of 139 premature infants with birth weight less than 1500g were collected from the NICU of Changsha Hospital for Maternal＆Child Health Care, from January 2017 to December 2019. According to whether be diagnosed as BPD, they were divided into the non-BPD group (n=81) and the BPD group (n=58). The differences between the two groups of premature infants in terms of maternal age, chorioamnionitis, gender, gestational age, and birth weight of the children were compared, and independent risk factors for BPD occurrence were analyzed by multivariate logistic regression.【Results】The proportion of mothers with chorioamnionitis and assisted conception in premature infants in the BPD group was higher than that in the non-BPD group, and the difference was statistically significant (P<0.05). The hospital stay of premature infants in the BPD group was higher than that in the non-BPD group. The proportion of males, invasive ventilator use, neonatal respiratory distress syndrome (NRDS), pulmonary surfactant (PS), neonatal pneumonia, and pharyngeal swab UU (ureaplasma urealyticum) positive tests in the BPD group were higher than those in non-BPD groups (P<0.05). Multivariate unconditional logistic regression analysis showed that gestational age and NRDS were the independent high-risk factors of very (extremely) low birth weight preterm infants.【Conclusion】The risk factors related to the development of bronchopulmonary dysplasia (BPD) in very (extremely) low birth weight premature infants were chorioamnionitis, birth weight, gestational age, NRDS, use of invasive ventilation and pharyngeal swab UU positive test. Of which, the gestational age and NRDS were independent risk factors.

Key words： Infant,Very Low Birth Weight Infant,Extremely Low Birth Weight Bronchopulmonary Dysplasia

收稿日期: 2020-03-25

PACS:

R72

基金资助:湖南省卫生计生委科研计划课题项目(课题编号:B2017228)

通讯作者: **E-mail:yelin3783@163.com

引用本文:

齐华雪, 吴敏, 陈铁强, 张路, 余宝梅, 戴津津. 极(超)低出生体质量早产儿支气管肺发育不良高危因素分析[J]. 医学临床研究, 2020, 37(6): 810-812.
QI Hua-xue, WU Min, CHEN Tie-qiang, et al. Risk Factors Analysis of Bronchopulmonary Dysplasia in Very (extremely) Low Birth Weight Premature Infants. JOURNAL OF CLINICAL RESEARCH, 2020, 37(6): 810-812.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.06.003 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I6/810

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