Abstract：【Objective】To study the effects of serum 25-(OH)D, vitamin D binding protein and cytokine levels on the development of bronchopulmonary dysplasia in preterm infants. 【Methods】A prospective analysis of 161 preterm infants delivered in our hospital from January 2016 to may 2019 was conducted. The patients were divided into observation group (BPD children) and control group (non BPD children) according to whether BPD occurred on the 28th day after birth. According to oxygen inhalation, BPD children were divided into mild BPD group and moderate severe BPD group. The levels of serum 25-(OH)D, TNF-α, IL-10 and VDBP in different groups were compared. The risk factors of BPD in preterm infants were analyzed by multivariate logistic regression. 【Results】The scores of Apgar/1min and Apgar/5min in in the observation group were significantly lower than those in the control group. The proportion of patent ductus arteriosus, delayed neonatal sepsis and neonatal pneumonia in the observation group was higher than that in the control group. The duration of continuous positive airway pressure, total oxygen inhalation time and hospitalization time in the observation group were longer than those in the control group (P<0.05). At birth, the levels of serum 25-(OH)D, VDBP and IL-10 in moderate and severe BPD group were lower than those in the mild BPD group (P<0.05). After 4 weeks, there was no significant difference in the levels of 25-(OH)D, VDBP and IL-10 between the two groups (P>0.05). Delayed neonatal sepsis, neonatal pneumonia and low levels of 25-(OH)D, VDBP and IL-10 may be associated with BPD in preterm infants. 【Conclusion】Delayed neonatal sepsis and neonatal pneumonia are the risk factors of BPD in preterm infants. The serum levels of 25-(OH)D, VDBP and IL-10 in children with BPD are decreased, which may be useful indicators for early prediction of BPD and assessment of its severity.
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2020, Vol. 37 
