Effect of GnRH-a Combined with Intrauterine Placement of LNG-IUS on Postoperative Recurrence, Reproductive Hormone, Dysmenorrhea and Serum CA125 in Patients with EMT
ZHANG Juan, HAN Xiao-man, XIAO Min-su
Department of Obstetrics and Gynecology, Meixian People's Hospital, Baoji Shaanxi 722300
Abstract：【Objective】 To investigate the effects of gonadotropin releasing agonist (GnRH-a) combined with levonorgestrel intrauterine sustained release system (LNG-IUS) on postoperative recurrence, reproductive hormone, dysmenorrhea, and serum glycoprotein 125 (CA125) in patients with endometriosis (EMT) postoperatively. 【Methods】 A total of 107 patients with EMT who underwent laparoscopic resection were enrolled in the study. Patients were randomly divided into the observation group (n=53) and the control group (n=54). The observation group received a gonadotropin-releasing agonist (GnRH-a) for 3 cycles after surgery, and then LNG-IUS was placed in the uterus; while the control group only received GnRH-a for 3 cycles of treatment after operation. The degree of dysmenorrhea (VAS score), serum CA125, Estrogen (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were compared between the two groups before and after surgery. The incidence of recurrence were followed up for 24 months. 【Results】 The dysmenorrhea degree (VAS) of the observation group was lower than that of the control group at 3 months, 12 months and 24 months after operation (P<0.05). There was no significant difference in the levels of E2,FSH, and LH between the two groups before and after operation (P>0.05). There was no significant difference in serum CA125 levels between the two groups before surgery (P>0.05);12 months after surgery, the serum CA125 level of the observation group was lower than that of the control group (P<0.05). After 24 months of follow-up, the recurrence rate of the observation group was 1.87% (1/53) , which was lower than that of the control group (12.96%,7/54). The difference was statistically significant (χ2=4.744, P<0.05).【Conclusion】 Intrauterine placement of LNG-IUS after EMT patients plays an important role in preventing recurrence, lowering serum CA125 level, and further alleviating dysmenorrhea.
张娟, 韩小曼, 肖敏素. 促性腺激素释放激动剂联合宫内放置LNG-IUS对EMT患者术后复发、痛经程度及性激素和CA125水平的影响[J]. 医学临床研究, 2021, 38(2): 237-239.
ZHANG Juan, HAN Xiao-man, XIAO Min-su. Effect of GnRH-a Combined with Intrauterine Placement of LNG-IUS on Postoperative Recurrence, Reproductive Hormone, Dysmenorrhea and Serum CA125 in Patients with EMT. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 237-239.
2021, Vol. 38 
