Abstract：【Objective】 To investigate the expression levels and significance of transforming growth factor β(TGF-β) and advanced glycation end products (AGEs) in anterior capsule tissue of lens and serum of diabetic patients with cataract. 【Methods】 Sixty-seven patients with diabetes mellitus complicated with cataract (the observation group) and 50 patients with simple cataract (the control group) were selected from January 2018 to January 2019 in our hospital. The expression of TGF-β protein in anterior capsular tissue of lens was detected by Western blot and the level of AGEs and HbA1c in serum was detected by ELISA. 【Results】 The relative expression of TGF-β protein in the lens anterior capsular tissue and serum AGEs of the observation group were (0.982±0.172) and (18.82±1.82)g/L, respectively, which were significantly higher than those of the control group (0.563±0.180) and (10.95±2.00) g/L, respectively. The differences were statistically significant (P<0.05). The serum AGEs level of patients with HbA1c ≥6.5% in the observation group was (19.96±1.88)g/L, which was significantly higher than that of patients with HbA1c <6.5% (17.78±1.89) g/L, the difference was statistically significant (P<0.05). 【Conclusion】 In diabetic patients with cataract, the levels of TGF-β in lens anterior capsule tissue and AGEs in serum increased. AGEs are related to glycosylated hemoglobin, TGF-β and AGEs may play a role in the process of diabetic cataract.
宋春花, 贺卫权. TGF-β蛋白、AGEs在糖尿病性白内障患者晶状体前囊膜组织和血清中的表达及其意义[J]. 医学临床研究, 2020, 37(10): 1497-1499.
SONG Chun-hua, HE Wei-quan. Influence of TGF-β Protein and AGEs Expression on Development of Cataract in Diabetic Patients. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1497-1499.
2020, Vol. 37 
