点阵激光联合复方倍他米松注射液对增生性瘢痕患者血清TGF-β1、BMP-7、EGF水平变化及预后的影响

doi:10.3969/j.issn.1671-7171.2018.01.010

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摘要【目的】探讨点阵激光联合复方倍他米松注射液对增生性瘢痕(HS)患者血清转化生长因子-β1(TGF-β1)、骨形态发生蛋白-7(BMP-7)、表皮生长因子(EGF)水平变化及预后的影响。【方法】抽取2013年11月至2016年10月汉中市人民医院98例HS患者,根据治疗方案分组,各49例。对照组给予单纯点阵激光治疗,观察组在此基础上联合复方倍他米松注射液治疗。对比两组治疗前后血清TGF-β1、BMP-7、EGF水平、负性情绪[焦虑自评量表(SAS)、抑郁自评量表(SDS)]评分及治疗后温哥华瘢痕评价量表(VSS)评分,统计两组不良反应发生率。【结果】①血清相关因子:治疗前,两组血清TGF-β1、BMP-7及EGF水平差异无统计学意义(P>0.05),治疗后,观察组血清TGF-β1、EGF水平低于对照组,BMP-7高于对照组,差异有统计学意义(P<0.05);②瘢痕评分:治疗后观察组VSS各维度评分均低于对照组,差异有统计学意义(P<0.05);③不良反应:观察组不良反应发生率为12.24%(6/49),对照组为10.20%(5/49),两组比较差异无统计学意义(P>0.05);④负性情绪:治疗前,两组SAS、SDS评分差异无统计学意义(P>0.05),治疗后,观察组SAS、SDS评分低于对照组,差异有统计学意义(P<0.05)。【结论】给予HS点阵激光联合复方倍他米松注射液治疗,可有效改善患者血清TGF-β1、BMP-7及EGF水平,促进瘢痕消退,且具有一定安全性,有利于缓解并消除患者负性情绪。

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	张小刚
	马驰蛟
	邬天刚
	冯登超

关键词 ：激光疗法, 倍他米松/药理学, 复方合剂, 注射剂, 瘢痕, 转化生长因子β1/血液, 骨形态发生蛋白质类/生物合成, 表皮生长因子/分析

Abstract：【Objective】To investigate the effects of dot matrix laser combined with compound betamethasone injection on serum transforming growth factor-β1 (TGF-β1), bone morphogenetic protein-7 (BMP-7), epidermal growth factor (EGF) levels and prognosis in patients with hypertrophic scar (HS).【Methods】From January 2013 to October 2016, 98 patients with HS in our hospital were selected and divided into control group and observation group according to the treatment plan, 49 cases in each group. The control group was given simple dot matrix laser treatment, the observation group received compound betamethasone injection treatment on the basis of the control group. The serum TGF-β1, BMP-7, EGF levels, negative emotions [ (SAS) and depression (SDS)] scores before and after treatment and post-treatment scar (VSS) scores after treatment were compared between the two groups, and the incidence of adverse reactions was statistically analyzed.【Results】 (1)Serum-related factors: Before treatment, the serum TGF-β1, BMP-7 and EGF levels were not statistically significant between the two groups (P>0.05).But after treatment, the serum TGF-β1 and EGF levels in the observation group were significantly lower than those in the control group and BMP-7 was significantly higher than that in the control group (P<0.05); (2) Scar score: The VSS each dimension scores in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05); (3) Adverse reactions: There was no significant difference in the incidence of adverse reactions between the observation group 12.24% (6/49) and the control group 10.20% (5/49) (P>0.05). (4) negative emotions: Before treatment, the SAS, SDS scores of the two groups were no significant difference (P>0.05), after treatment, the SAS and SDS scores in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05).【Conclusion】Treatment of HS using dot matrix laser combined with betamethasone injection can effectively improve the serum TGF-β1, BMP-7 and EGF levels, promote the scar to subside with safety, it is helpful to alleviate and eliminate the negative emotions.

Key words： Laser Therapy Betamethasone/PD Drug Combinations INJECTIO Cicatrix Transforming Growth Factor beta1/BL Bone Morphogenetic Proteins/BI Epidermal Growth Factor/AN

收稿日期: 2017-03-22

PACS:

R619.6

引用本文:

张小刚,马驰蛟,邬天刚,冯登超. 点阵激光联合复方倍他米松注射液对增生性瘢痕患者血清TGF-β1、BMP-7、EGF水平变化及预后的影响[J]. 医学临床研究, 2018, 35(1): 33-36.
ZHANG Xiao-gang,MA Chi-jiao,WU Tian-gang,et al. Effects of Dot Matrix Laser Combined with Compound Betamethasone Injection on Serum TGF-β1, BMP-7, EGF Level Changes and Prognosis in Patients with Hypertrophic Scar. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 33-36.

链接本文:

http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2018.01.010 或 http://www.jcr.net.cn/CN/Y2018/V35/I1/33

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