Abstract：【Objective】To investigate the changes and significance of monocyte scavenger receptor (CD163), serum carbohydrate antigen 125 (CA125) and growth differentiation factor-15 (GDF-15) in peripheral blood of patients with chronic heart failure (CHF). 【Methods】A total of 140 patients with CHF diagnosed in our hospital (the CHF group) from March 2017 to May 2018 and 70 healthy volunteers (the control group) from the same period were selected for the study. The levels of peripheral blood CD163, serum CA125 and GDF-15 were compared between the two groups. Cardiac function indicators: left ventricular end-diastolic (LVEDD), left ventricular ejection fraction (LVEF), left ventricular anteroposterior diameter (LAD), left ventricular relative wall thickness (RWT) were compared as well.【Results】The levels of CD163, serum CA125 and GDF-15 in peripheral blood of patients with CHF were significantly higher than those of the control group (P<0.05). The LVEDD and LAD in the observation group were significantly higher than those in the control group, while the LVEF and RWT were significantly lower than those in the control group; And the differences were statistically significant (P<0.05). The value of LVEF was negatively correlated with levels of serum CD163, CA125 and GDF-15 in patients with CHF (rCD163=-0.729, rCA125=-0.638, rGDF-15=-0.552,P<0.05).【Conclusion】The levels of serum CD163, CA125 and GDF-15 in patients with chronic heart failure were significantly increased. The increase was significantly negatively correlated with LVEF values.
[1] Morici N. Management of cardiogenic shock in acute decompensated chronic heart failure: The ALTSHOCK phase II clinical trial[J].Am Heart J,2018,34(6):90-94. [2] 李志强,王春燕,石毅,等. 慢性心力衰竭患者血红蛋白清道夫受体CD163的表达及意义[J].岭南心血管病杂志,2018,24(1):60-65. [3] 汤子鸣,秦俭. 急性心力衰竭患者联合检测血清糖类抗原CA125和N末端脑钠肽原的临床意义[J].中国现代医学杂志,2016,26(24):51-53. [4] 殷华,马少雯,杜一平. 生长分化因子-15对慢性心力衰竭患者左室重构的预测价值[J].中华老年多器官疾病杂志,2017,16(09):659-662. [5] Lu X, Zhang L, Wang J,et al. Clinical Efficacy and Safety of Xinmailong Injection for the Treatment of Chronic Heart Failure: A Meta-Analysis[J].Front Pharmacol,2018,9(6):34-36. [6] Li Z. Clinical efficacy and safety of nuanxin capsule for chronic heart failure[J].Medicine,2018,97(27):339-341. [7] 陈怡粤,余小平,陈胜华. 心力衰竭超声指数评价射血分数中间范围型心力衰竭的临床价值[J].中国老年学杂志,2018,38(10):2342-2344. [8] 王春燕,李锦玉,李志强,等. 慢性心衰病人血红蛋白清道夫受体CD163表达及其与心功能的关系[J].中西医结合心脑血管病杂志,2017,15(3):327-331. [9] 陈健新,陈广基,徐浩. 老年心力衰竭患者血清CA125水平的变化及意义[J].中国老年学杂志,2016,36(21):5312-5313. [10] 张玉涛,王建春. 慢性心力衰竭患者超敏肌钙蛋白T及生长分化因子15的临床诊断价值探讨[J].中国临床医生杂志,2017,45(4):37-39. [11] 洪飞,汪磊. 慢性心力衰竭患者血清CA125、hs-CRP和TNF-α水平及其与心功能的关系[J].中国医科大学学报,2017,46(9):787-790.
2019, Vol. 36 
