Abstract：【Objective】 To investigate the changes and significance of platelet activating complex 1 (PAC-1), leukocyte differentiation antigen 40 Ligand (CD40L) and platelet membrane glycoprotein CD62P in patients with unstable angina pectoris (UAP).【Methods】 The clinical data (observation group) of 90 UAP patients admitted to our hospital from January 2017 to January 2018 were selected, and 100 healthy volunteers were selected as the control group to detect the levels of PAC-1, CD40L and CD62p in the peripheral blood of the two groups, and to analyze the correlation between the levels of PAC-1, CD40L and CD62p in the serum of UAP patients and the severity grading of UAP (Braunwald grading).【Results】 The levels of PAC-1, CD40L and CD62p in the observation group were significantly higher than those in the control group (P<0.05). The levels of PAC-1, CD40L and CD62p in patients with Braunwald grade Ⅲ were significantly higher than those in patients with grade Ⅰ and grade Ⅱ (P<0.05);The serum levels of PAC-1, CD40L and CD62p in Braunwald grade Ⅱ patients were significantly higher than those in grade Ⅰ patients (P<0.05). The serum levels of PAC-1, CD40L and CD62p were positively correlated with Braunwald grade (mean P<0.05).【Conclusion】 The expression of PAC-1, CD40L and CD62p in serum of UAP patients is increased, which is positively correlated with the severity of the disease.
王立鹤, 王继鹏, 沈晓娟, 张辉, 曹义战. 不稳定心绞痛患者血清PAC-1、CD40L、CD62p水平的变化及其意义[J]. 医学临床研究, 2020, 37(4): 570-572.
WANG Li-he, WANG Ji-peng, SHEN Xiao-juan, et al. Changes and Significance of Serum PAC-1, CD40L and CD62p Levels in Patients with Unstable Angina. JOURNAL OF CLINICAL RESEARCH, 2020, 37(4): 570-572.
2020, Vol. 37 
