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医学临床研究  2020, Vol. 37 Issue (8): 1128-1132    DOI: 10.3969/j.issn.1671-7171.2020.08.003
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有情感迟钝精神分裂症患者的失匹配负波研究
唐佩茜, 孙巧玲, 谭立文**
中南大学湘雅二医院精神卫生研究所,湖南 长沙 410011
A study of Mismatch Negativity in Schizophrenic Patients with Affective Retardation
TANG Pei-xi, SUN Qiao-ling, TAN Li-wen
Department of Psychiatry, The Second Xiangya Hospital, Central South University Changsha, Hunan 410011
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摘要 目的】 探讨精神分裂症患者情感迟钝症状与事件相关电位(event-related potential,ERP)中失匹配负波(mismatch negativity,MMN)的关系。【方法】 选取首发未用药或停药四周以上的有情感迟钝症状与无情感迟钝症状的精神分裂症患者、健康受试者各15例,记录所有受试者在听觉oddball范式下的ERP数据,比较三组受试者的MMN潜伏期及波幅的差异。【结果】 (1)MMN波幅:在额区,无情感迟钝组的MMN波幅较健康对照组降低,而有情感迟钝组额区MMN波幅较前两者均降低。在中央区、左侧和右侧,仅发现有情感迟钝组的MMN波幅较健康对照组降低;在中间,有情感迟钝组和无情感迟钝组的MMN波幅较健康对照组都降低,但两患者组间未发现统计学差异。(2)MMN潜伏期,三组间差异无统计学差异。【结论】 本研究发现精神分裂症患者前注意加工过程受损,而伴有情感迟钝症状的患者其前注意加工过程受损程度更严重。
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唐佩茜
孙巧玲
谭立文
关键词 精神分裂症脑电描记术    
Abstract:【Objective】 To investigate the relationship between the symptoms of emotional retardation and mismatch negativity (MMN) in event-related potential (ERP) in schizophrenia.【Methods】 Fifteen schizophrenic patients with and without affective retardation symptoms and 15 healthy subjects were selected as the subjects without medication or withdrawal for more than four weeks. The ERP data of all subjects under the auditory oddball paradigm were recorded, and the differences of MMN latency and amplitude among the three groups were compared. 【Results】 (1) MMN amplitude: in frontal region, the amplitude of MMN in the non affective group was lower than that in the healthy control group, while the MMN amplitude in the frontal region in the emotional retardation group was lower than that in the former two groups. In central area, left side and right side, only the MMN amplitude of patients with affective retardation was lower than that of healthy control group; in the middle, MMN amplitude of patients with and without affective retardation was lower than that of healthy control group, but there was no significant difference between the two groups. (2) There was no significant difference in MMN latency among the three groups.【Conclusions】 This study found that the process of pre attention processing is impaired in schizophrenic patients, and the degree of impairment is more serious in patients with emotional retardation.
Key wordsSchizophrenia    Electroencephalography
收稿日期: 2020-08-03     
PACS:  R749.3  
基金资助:军委后勤保障部卫生局重点项目(18CXZ012);湖南省卫生适宜技术推广项目(WZ2020-16);湖南省自然科学基金面上项目 (2020JJ4807)
通讯作者: **Email:tanliwen@csu.edu.cn   
引用本文:   
唐佩茜, 孙巧玲, 谭立文. 有情感迟钝精神分裂症患者的失匹配负波研究[J]. 医学临床研究, 2020, 37(8): 1128-1132.
TANG Pei-xi, SUN Qiao-ling, TAN Li-wen. A study of Mismatch Negativity in Schizophrenic Patients with Affective Retardation. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1128-1132.
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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.08.003     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I8/1128
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