Abstract:【Objective】To explore the clinical effect and value of splenomegaly lymph node (No.10) and paraarterial lymph node (No.11) preserved in D2 radical gastrectomy. 【Methods】Sixty-six patients with advanced gastric cancer were divided into observation group (30 cases,lymph node dissection with spleen No.10 and No.11 preserved in D2 radical gastrectomy) and control group (36 cases, D2 radical gastrectomy combined with splenectomy for gastric cancer) according to the operation method.The operation time, bleeding volume, hospitalization time, number of lymph nodes, positive lymph node detection rate, operation complication rate and 1-year and 3-year survival rate were compared between the two groups. 【Results】The operation time of the observation group was longer than that of the control group, and the bleeding volume and hospitalization time of the operation were lower than those of the control group (P<0.05). There was no significant difference between the two groups in the number of lymph nodes cleaned and the detection rate of positive lymph nodes (P>0.05). The incidence of surgical complications in the observation group was 13.33% (4 / 30) lower than that in the control group (30.56% 11/ 36). The difference was statistically significant (χ2= 4.44, P<0.05). There was no significant difference between the observation group and the control group (P>0.05); there was no significant difference between the observation group and the control group (P>0.05). The median 3-year survival time was 32.0 months in the observation group and 29.0 months in the control group, there was no significant difference (P>0.05). 【Conclusion】Lymph node dissection with spleen No.10 and No.11 preserved in D2 radical gastrectomy have similar clinical effect and prognosis with splenectomy, and have lower complication rate and less trauma.