Abstract：【Objective】To investigate the short-term efficacy and long-term prognosis of different surgical methods for treating diffuse proximal advanced gastric cancer (AGC).【Methods】A total of 80 patients with diffuse proximal AGC treated in our hospital from February 2011 to April 2014 were enrolled in the study. They were randomly divided into two groups by random number table method, with 40 cases in each group. The observation group (A group) was treated with total gastrectomy, while the control group (B group) was treated with proximal gastrectomy (partial resection). All patients were followed up for 3 years after surgery. The general data, early recovery after surgery, hemoglobin (Hb), albumin (Alb), total protein (TP), 3-year survival rates, tumor-free survival rates and recurrence rates were compared between the two groups.【Results】The surgical time was shorter and intraoperative blood loss was less in the A group compared to those of the B group (P<0.05), while the number of dissected lymph nodes was significantly more than that in the B group (P<0.05). Levels of plasma Hb, Alb and TP one year after surgery in both groups were decreased (P<0.05), but there was no significant difference between the two groups (P>0.05). The 3-year survival rate (53.33%) and tumor-free survival rate (46.67%) of the A group were higher than those of the B group (31.11% and 22.22%, respectively;P<0.05), while there was no significant difference in recurrence rate between the two groups (P>0.05). The incidence of complications in the A group within 3 years after surgery was significantly lower than that in the B group (P<0.05).【Conclusion】The short-term efficacy of total gastrectomy is a good way to treat diffuse proximal AGC. It can shorten the surgical time, reduce intraoperative blood loss, increase the number of dissected lymph nodes, and significantly improve the 3-year survival rate and tumor-free survival rate of patients.
蒋强. 不同手术方式治疗弥漫型近端进展期胃癌患者的近期疗效及远期预后[J]. 医学临床研究, 2018, 35(4): 654-656.
JIANG Qiang. Short-term Efficacy and Long-term Prognosis of Patients with Diffuse Proximal Advanced Gastric Cancer Treated with Different Surgical Methods. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 654-656.
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2018, Vol. 35 
