Abstract：【Objective】To investigate the relationship between recurrence and metastasis and the expression of thioredoxin-1 (Trx-1) after radical resection of distal gastric cancer.【Methods】A total of 139 patients who underwent radical resection of distal gastric cancer in our hospital were collected in the study. It included 62 cases of recurrence and metastasis (recurrence group) and 77 cases of non recurrence and metastasis (non-recurrence group).. The expression of Trx-1 was detected by immunohistochemical staining, and its relationship with recurrence and metastasis after radical resection of distal gastric cancer was analyzed.【Results】The positive expression rate of Trx-1 in the tissues of recurrence patients (87.10±8.72)% was significantly higher than those in the tissues of non-recurrence patients and normal tissues [ (25.58±10.25)% and (10.25±3.14)%] (P<0.05). There was no significant difference in the positive rate of Trx-1 between normal and non-recurrent patients (P>0.05). Among 62 recurrent cases, the median disease-free survival time of patients with high expression was (13.5±2.84) months, which was shorted than that of patients with low expression with (18.6±3.58) months. Multivariate Cox model showed that high expression of Trx-1, TNM stages, tumor size and lymph node metastasis were the independent factors for the disease-free survival of patients with gastric cancer.【Conclusion】The increased expression of Trx-1 is associated with the shortening of disease-free survival time after radical resection of distal gastric cancer. Trx-1 can be used as a marker for predicting recurrence and metastasis of distal gastric cancer after radical resection.
潘涛. 远端胃癌根治术术后复发转移与硫氧化还原蛋白-1表达的关系[J]. 医学临床研究, 2018, 35(2): 251-253.
PAN Tao. Relationship between Recurrence and Metastasis and Expression of Thioredoxin -1 after Radical Resection of Distal Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 251-253.
2018, Vol. 35 
