Abstract:【Objective】To investigate the effect of transesophageal echocardiography (TEE) capacity guidance rehydration on the renal function indexes macroglobulin (β2-MG), proteinuria and urinary creatinine (UCr) in patients undergoing laparoscopic radical cystectomy of bladder cancer. 【Methods】A total of 160 patients with bladder cancer were enrolled. They were randomly divided into the TEE capacity guidance rehydration treatment group (observation group) and the conventional rehydration treatment group (control group), with 80 cases in each group. Data of cardiac function, major renal function index and postoperative complications in patients were recorded and compared in the tow groups. 【Results】There were no significant differences in the above indexes between the two groups before operation (P>0.05). Compared to the control group, the levels of renal function indexes β2-MG, BUN, SCr, UCr and 24h urine protein in the observation group were much lower; the differences were statistically significant (P<0.05). The hospitalization time of the observation group was (11.36±1.47)d, which was significantly less than that of the control group (16.23±1.51)d, and the difference was significant (P<0.05). The incidence of early complications and late complications were significantly lower in the observation group than in the control group (P<0.05).【Conclusion】TEE capacity guidance rehydration therapy can effectively improve postoperative renal function and reduce postoperative complications.