Abstract:【Objective】To explore the clinical effect of emergency laparoscopic splenectomy (LS) in the treatment of traumatic splenic rupture. 【Methods】The clinical data of 82 patients with traumatic splenic rupture in our hospital were analyzed retrospectively. According to the operation method, they were divided into two groups: the observation group (LS operation,n=43) and the control group (exploratory laparotomy and total splenectomy,n=39). The operation time, intraoperative hemorrhage, postoperative exhaust time, hospitalization time and complications were compared between the two groups. The levels of WBC, IL-6, cor and TNF - α were compared before and 3 days after operation. 【Results】The operation time of the observation group was longer than that of the control group, and the postoperative exhaust time, average hospitalization time and intraoperative bleeding volume of the observation group were less than those of the control group (P<0.05). The level of Cor, TNF -α, IL-6 water in the two groups was higher than that before operation on the 3rd day after operation, and the WBC level in the control group was higher than that before operation on the 3rd day after operation, the difference was statistically significant (P<0.05); the level of Cor, TNF -α, IL-6, WBC in the observation group was lower than that in the control group on the 3rd day after operation, the difference was statistically significant (P<0.05). The incidence of complications in the observation group was 6.98% (3/43) lower than that in the control group 23.08% (9/39), the difference was statistically significant (χ2=-6.270, P<0.05).【Conclusion】Patients with traumatic splenic rupture after LS have less trauma, less complications, less stress and inflammatory response, and quick recovery, which is worthy of clinical application.