Abstract：【Objective】To investigate the efficacy of anticancer regimen combined with gefitinib in the treatment of cancer-related fatigue and its impact on quality of life. 【Methods】A total of 123 patients with advanced non-small cell lung cancer (NSCLC) were divided into two groups according to the treatment methods. Patients in the control group(group B)received gefitinib, while patients in the observation group(group A) received gefitinib combined with anti-cancer treatment. The therapeutic effects, quality of life scores and the PFS score in the two groups before and after treatment were compared. 【Results】The PFS scores of the two groups were lower than those before treatment (P<0.05), and the decrease in group A was higher than that in group B (P<0.05). After treatment, the fatigue, rib pain, five upset fever and pulse weakness scores of the two groups were lower than before treatment (P<0.05).Those scores in group A were significantly lower than group B (P<0.05). The total remission rate of group A was 69.68%, which was significantly higher than group B (40.98%) (P<0.05). After treatment, the scores of physical function, role function and emotional function in the two groups were higher than those before treatment (P<0.05). The increase in the above scores in group A was higher than group B (P<0.05). Regression analysis showed that age and pathological grade were negatively correlated with quality of life in patients with advanced NSCLC. However, psychological intervention and treatment were positively correlated with quality of life in those patients. 【Conclusion】Anticancer combined with gefitinib is effective in treating cancer-related fatigue in patients with advanced NSCLC , and can significantly improve the quality of life of patients.
黄凤灵, 李健哲. 抗癌方联合吉非替尼治疗晚期NSCLC患者癌因性疲乏的疗效及对生活质量的影响[J]. 医学临床研究, 2019, 36(5): 833-835.
HUAHG Feng-lin, LI Jian-zhe. Efficacy of Anticancer Regimen Combined with Gefitinib in the Treatment of Cancer-related Fatigue in Advanced Non-small Cell Lung Cancer Patient. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 833-835.
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2019, Vol. 36 
