Therapeutic Effect of Probucol Combined with Rosuvastatin in the Treatment of Carotid Atherosclerotic Plaque in Patients with Cerebral Infarction Complicated with Diabetes
SHUDan, CHENTing-yan, LIANGDan
Department of Internal Medicine, Xinhua Hospital of Chengdu, Chengdu, Sichuan 610051
Abstract：【Objective】 To investigate the efficacy of probucol combined with rosuvastatin in the treatment of carotid atherosclerotic plaques in patients with cerebral infarction complicated with type 2 diabetes mellitus (T2DM). 【Methods】 A total of 126 patients with cerebral infarction combined with T2DM who were treated in our hospital from February 2016 to August 2014 were selected as the research subjects. The patients were randomly divided into the observation group and the control group, with 63 cases in each group. Patients in the control group received rosuvastatin alone, while patients in the observation group received ropucol combined with rosuvastatin. Patients in both groups were treated for 1 year. The results of carotid artery ultrasound examination, the indexes of blood lipid and inflammatory factors, protein S100 beta, microalbuminuria, and neurological status determination (NIHSS evaluation) between the two groups were compared before and after treatment. The incidence of adverse reactions was recorded at the same time. 【Results】 After treatment, the carotid intima-media thickness (CAIMT), endometrial plaque area and the detection rate of vulnerable plaque were lower in both groups than those before treatment (P<0.05), and those in the observation group decreased more significantly (P<0.05). After treatment, total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were lower than those before treatment (P>0.05), while the level of high-density lipoprotein cholesterol (HDL-C) was higher than that before treatment. The changes in the observation group were more remarkable with statistical significance (P<0.05). Levels of protein S100 beta, urinary microalbumin and stroke scale (NIHSS) score, high-sensitivity C-raction protein )hs-CRP), interleukin 6 (IL-6) and tumor necrosis factor (TNF-α) in both groups decreased after treatment (P<0.05), and the decrease in the observation group was more obvious than those in the control group (P<0.05). The incidence of adverse reactions such as headache, dizziness, rash, nausea and vomiting, myalgia, hepatorenal dysfunction and gastrointestinal reactions in the two groups were not statistically different (P>0.05). 【Conclusion】 Probucol combined with rosuvastatin is more effective in the treatment of cerebral infarction with diabetes mellitus. It is worthy of clinical application.
舒丹, 陈廷燕, 梁丹. 普罗布考联合瑞舒伐他汀治疗脑梗死合并糖尿病患者的疗效观察[J]. 医学临床研究, 2018, 35(8): 1499-1501.
SHUDan, CHENTing-yan, LIANGDan. Therapeutic Effect of Probucol Combined with Rosuvastatin in the Treatment of Carotid Atherosclerotic Plaque in Patients with Cerebral Infarction Complicated with Diabetes. JOURNAL OF CLINICAL RESEARCH, 2018, 35(8): 1499-1501.
2018, Vol. 35 
