不同OCT分型的视网膜静脉阻塞性黄斑水肿与血清中血管内皮生长因子水平的相关性

doi:10.3969/j.issn.1671-7171.2026.03.026

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摘要 【目的】探讨不同光学相干断层扫描(OCT)分型的视网膜静脉阻塞性黄斑水肿(RVO-ME)与血清中血管内皮生长因子(VEGF)水平的相关性。【方法】回顾性分析2022年12月至2024年12月本院眼科诊治的138例(138眼)RVO-ME患者的临床资料,根据视网膜静脉阻塞部位分为视网膜中央静脉阻塞组和视网膜分支静脉阻塞组;根据OCT特征将RVO-ME患者分为弥漫性视网膜增厚型组(n=25)、浆液性视网膜脱离型组(n=58)、黄斑囊样水肿型组(n=55)。同时,选取在本院眼科诊治且已排除眼底疾病的50例(50眼)白内障手术患者作为对照组。测量各组患者血清VEGF水平并比较。【结果】视网膜中央静脉阻塞组和视网膜分支静脉阻塞组的血清VEGF水平均显著高于对照组(P<0.05)。弥漫性视网膜增厚型组、浆液性视网膜脱离型组和黄斑囊样水肿型组RVO-ME患者视网膜中央静脉阻塞和视网膜分支静脉阻塞分布比较,差异有统计学意义(P<0.05)。不同OCT分型的RVO-ME患者血清中VEGF水平比较,差异有统计学意义(P<0.05)。【结论】不同OCT分型的RVO-ME患者血清中VEGF水平存在差异,且与视网膜静脉阻塞的部位和黄斑水肿的类型密切相关,这提示了VEGF可能在RVO-ME的发病和发展中发挥重要作用。

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	胡旭萌
	王菲艳

关键词 ：黄斑水肿, 视网膜静脉闭塞, 血管内皮生长因子A, 数据相关性

Abstract：【Objective】 To investigate the correlation between different optical coherence tomography (OCT) classifications of retinal vein occlusion macular edema (RVO-ME) and serum vascular endothelial growth factor (VEGF) levels. 【Methods】 Clinical data of 138 patients (138 eyes) with RVO-ME diagnosed and treated in the ophthalmology department of our hospital from December 2022 to December 2024 were retrospectively analyzed. According to the site of retinal vein occlusion, patients were divided into central retinal vein occlusion group and branch retinal vein occlusion group. According to OCT features, RVO-ME patients were classified into diffuse retinal thickening type group (n=25), serous retinal detachment type group (n=58), and cystoid macular edema type group (n=55). Meanwhile, 50 patients (50 eyes) undergoing cataract surgery who were diagnosed and treated in our ophthalmology department and excluded from fundus diseases were selected as the control group. Serum VEGF levels were measured and compared among all groups. 【Results】 Serum VEGF levels in both central retinal vein occlusion group and branch retinal vein occlusion group were significantly higher than those in the control group (P<0.05). There were statistically significant differences in the distribution of central retinal vein occlusion and branch retinal vein occlusion among diffuse retinal thickening type, serous retinal detachment type and cystoid macular edema type RVO-ME patients (P<0.05). Statistically significant differences were found in serum VEGF levels among RVO-ME patients with different OCT classifications (P<0.05). 【Conclusion】 Serum VEGF levels differ in RVO-ME patients with different OCT classifications, and are closely related to the site of retinal vein occlusion and the type of macular edema, suggesting that VEGF may play an important role in the pathogenesis and progression of RVO-ME.

Key words： Macular Edema Retinal Vein Occlusion Vascular Endothelial Growth Factor A Correlation of Data

收稿日期: 2025-02-19

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R774.5

引用本文:

胡旭萌, 王菲艳. 不同OCT分型的视网膜静脉阻塞性黄斑水肿与血清中血管内皮生长因子水平的相关性[J]. 医学临床研究, 2026, 43(3): 446-448.
HU Xumeng, WANG Feiyan. Correlation between Different OCT Classifications of Retinal Vein Occlusion Macular Edema and Serum Vascular Endothelial Growth Factor Levels. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 446-448.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.03.026 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I3/446

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