HGI、cys C水平与糖尿病视网膜病变程度的相关性

doi:10.3969/j.issn.1671-7171.2026.03.016

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摘要 【目的】探讨糖化血红蛋白变异指数(HGI)、胱抑素C(cys C)水平与糖尿病视网膜病变程度的相关性。【方法】选取2023年6月至2024年10月在本院诊治的170例糖尿病视网膜病变患者,根据糖尿病视网膜病变程度分为非增殖期病变组(n=98)和增殖期病变组(n=72),另选取83例单纯糖尿病患者作为对照组(单纯糖尿病组),分析HGI、cys C水平与糖尿病视网膜病变程度的相关性。【结果】增殖期病变组患者高HGI占比、cys C水平均高于非增殖期病变组和单纯糖尿病组(P<0.05)。HGI、cys C水平均与糖尿病视网膜病变程度呈正相关(P<0.05)。增殖期病变组患者糖尿病病程、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、高HGI占比、cys C均高于非增殖期病变组(P<0.05)。糖尿病病程、HbA1c水平高、高HGI、cys C水平高均是影响糖尿病视网膜增殖期病变的独立危险因素(P<0.05);HGI联合cys C水平预测糖尿病视网膜增殖期病变的灵敏度、特异度和曲线下面积(AUC)分别为80.56%、97.96%、0.893。【结论】HGI、cys C水平均与糖尿病视网膜病变密切相关,临床检测HGI、cys C水平可作为预测糖尿病视网膜增殖期病变的敏感指标。

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	王菲艳
	胡旭萌
	李乐

关键词 ：糖尿病视网膜病变, 抑素类, 数据相关性

Abstract：【Objective】 To explore the correlation of glycated hemoglobin variability index (HGI) and cystatin C (cys C) levels with the severity of diabetic retinopathy. 【Methods】 A total of 170 patients with diabetic retinopathy treated in our hospital from June 2023 to October 2024 were selected and divided into the non-proliferative retinopathy group (n=98) and the proliferative retinopathy group (n=72) based on the severity of diabetic retinopathy. Additionally, 83 patients with simple diabetes were selected as the control group (simple diabetes group). The correlations between HGI, cys C levels and the severity of diabetic retinopathy were analyzed. 【Results】 The proportion of high HGI and cys C levels in the proliferative retinopathy group were higher than those in the non-proliferative retinopathy group and the simple diabetes group (P<0.05). Both HGI and cys C levels were positively correlated with the severity of diabetic retinopathy (P<0.05). The duration of diabetes, fasting blood glucose (FPG), glycated hemoglobin (HbA1c), proportion of high HGI and cys C levels in the proliferative retinopathy group were higher than those in the non-proliferative retinopathy group (P<0.05). The duration of diabetes, HbA1c, high HGI and cys C were independent risk factors for proliferative diabetic retinopathy (P<0.05). The sensitivity, specificity and AUC of the combined HGI and cys C levels in predicting proliferative diabetic retinopathy were 80.56%, 97.96% and 0.893, respectively. 【Conclusion】 Both HGI and cys C levels are closely related to diabetic retinopathy. The clinical detection of HGI and cys C levels can be used as sensitive indicators for predicting proliferative diabetic retinopathy.

Key words： Diabetic Retinopathy Chalones Correlation of Data

收稿日期: 2025-12-26

中图分类号:

R587.1

引用本文:

王菲艳, 胡旭萌, 李乐. HGI、cys C水平与糖尿病视网膜病变程度的相关性[J]. 医学临床研究, 2026, 43(3): 411-414.
WANG Feiyan, HU Xumeng, LI Le. Correlation of HGI and cys C Levels with Diabetes Retinopathy. JOURNAL OF CLINICAL RESEARCH, 2026, 43(3): 411-414.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2026.03.016 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2026/V43/I3/411

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