Abstract：【Objective】 To investigate the correlation and predictive value of serum angiopoietin-like protein 8(ANGPTL8), soluble intercellular adhesion molecule-1(sICAM-1), and soluble fms-like tyrosine kinase-1(sFlt-1) levels with the occurrence of cerebrovascular vasospasm(CVS) after interventional therapy in patients with intracranial aneurysm(ICA).【Methods】 A total of 90 ICA patients were enrolled and divided into the CVS group(38 cases) and non-CVS group(52 cases) according to whether CVS occurred after surgery. Serum levels of ANGPTL8, sICAM-1, and sFlt-1 were compared between the two groups. Logistic regression was used to analyze influencing factors for postoperative CVS. Receiver operating characteristic(ROC) curves were employed to assess the diagnostic value of ANGPTL8, sICAM-1, and sFlt-1 in predicting CVS after interventional therapy.【Results】 The proportions of patients with hypertension, Hunt-Hess grade Ⅲ-Ⅳ, and Glasgow Coma Scale(GCS) score of 3-8 were significantly higher in the CVS group compared with the non-CVS group(P<0.05). Serum ANGPTL8, sICAM-1, and sFlt-1 levels were also significantly higher in the CVS group(P<0.05). Logistic univariate analysis showed that hypertension history, Hunt-Hess grade, GCS score, ANGPTL8, sICAM-1, and sFlt-1 were all risk factors for postoperative CVS(all P<0.05). Multivariate analysis further indicated that hypertension history, Hunt-Hess grade, GCS score, VCAM-1, ANGPTL8, sICAM-1, and sFlt-1 were independent risk factors for postoperative CVS(P<0.05). ROC curve analysis demonstrated that combined detection of serum ANGPTL8, sICAM-1, and sFlt-1 achieved the highest diagnostic efficiency(P<0.05).【Conclusion】 Significant elevations in serum ANGPTL8, sICAM-1, and sFlt-1 are closely associated with the occurrence of CVS after interventional therapy in ICA patients. These biomarkers may help in the early identification of high-risk CVS patients.
常慧, 史志鹏, 董树晓. 血清ANGPTL8、sICAM-1、sFlt-1与颅内动脉瘤患者介入术后发生脑血管痉挛的相关性[J]. 医学临床研究, 2025, 42(9): 1591-1593.
CHANG Hui, SHI Zhipeng, DONG Shuxiao. Correlation of Serum ANGPTL8, sICAM-1, and sFlt-1 with Cerebrovascular Vasospasm after Interventional Therapy in Patients with Intracranial Aneurysm. JOURNAL OF CLINICAL RESEARCH, 2025, 42(9): 1591-1593.
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2025, Vol. 42 
