Effect of Digital Subtraction Angiography-Guided Neurointerventional Thrombolysis on Vascular Endothelial Function in Patients with Acute Cerebral Infarction
ZHANG Min, ZHAO Baoping, HAO Xiangyu
Department of Neurology, Shangqiu Municipal Hospital, Shangqiu Henan 450000
Abstract：【Objective】 To investigate the effect of digital subtraction angiography(DSA)-guided neurointerventional thrombolysis on vascular endothelial function in patients with acute cerebral infarction(ACI).【Methods】 A total of 86 patients with ACI undergoing thrombolytic therapy were randomly divided into two groups, with 43 patients in each group. The control group received intravenous thrombolysis, while the observation group was treated with DSA-guided neurointerventional thrombolysis. Vascular endothelial function [flow-mediated dilation(FMD), nitric oxide(NO), endothelin-1(ET-1), thromboxane A2(TXA2)], hemodynamic parameters [mean blood flow(Qm), pulse wave velocity(Wv), characteristic impedance(ZCV), peripheral resistance(RV)], serum neuronal injury markers [homocysteine(Hcy), nerve growth factor(NGF), neuron-specific enolase(NSE), brain-derived neurotrophic factor(BDNF)], and neurological function [Chinese Stroke Scale of Slinical Neurological Deficit Grade(CSS) and National Institutes of Health Stroke Scale(NIHSS) scores] were compared between the two groups before and after treatment.【Results】 After treatment, FMD and NO levels in the observation group were significantly higher, while ET-1 and TXA2 levels were significantly lower than those in the control group(all P<0.05). The observation group also showed higher Qm and lower Wv, ZCV, and RV(all P<0.05)than the control group. Levels of Hcy and NSE were lower, while NGF and BDNF were higher in the observation group compared to the control group(all P<0.05). Additionally, CSS and NIHSS scores in the observation group were significantly lower than those in the control group(P<0.05).【Conclusion】 DSA-guided neurointerventional thrombolysis in ACI patients can effectively improve cerebral blood flow parameters and vascular endothelial function, thereby promoting neurological recovery.
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2025, Vol. 42 
