NETs与不稳定型心绞痛患者PCI术后短期预后的相关性

doi:10.3969/j.issn.1671-7171.2025.07.012

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摘要【目的】探讨中性粒细胞胞外诱捕网(NETs)与不稳定型心绞痛(UAP)患者经皮冠状动脉介入治疗(PCI)术后短期预后的相关性。【方法】选取2019年9月至2023年9月本院收治的215例行PCI的UAP患者,根据患者PCI术后30 d内预后情况将患者分为预后良好组(n=138)和预后不良组(n=77)。比较两组血清dsDNA/NETs、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、髓过氧化物酶(MPO)、肌酸激酶同工酶-MB(CK-MB)、肌钙蛋白I(cTnI),以及血小板计数、白细胞计数、血小板平均体积(MPV)。采用Pearson分析血清dsDNA/NETs与各指标的相关性,采用Logistic回归模型分析UAP患者PCI术后发生不良心血管事件的危险因素,采用受试者工作特征(ROC)曲线分析术后24 h血清dsDNA/NETs水平对UAP患者发生不良心血管事件的预测价值。【结果】术后24 h,两组患者血清dsDNA/NETs、CRP、CK-MB、cTnI、TNF-α、IL-10、MPO水平高于术前,且预后不良组高于预后良好组,MPV、PLT水平低于术前,且预后不良组低于预后良好组,差异有统计学意义(P<0.05)。UAP患者术后24 h血清dsDNA/NETs水平与MPV、PLT水平均呈负相关(r=－0.382、－0.527,均P<0.05)。多因素Logistic回归分析显示,dsDNA/NETs、CRP、CK-MB水平高,MPV水平低是UAP患者PCI术后发生不良预后的危险因素(P<0.05)。血清dsDNA/NETs水平预测UAP患者PCI术后发生不良预后的曲线下面积为0.860,敏感度为84.40%,特异度为83.80%。【结论】UAP患者PCI术后血清dsDNA/NETs水平明显升高,可用于评估UAP患者PCI术后短期不良心血管事件发生情况。

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	陈建国

关键词 ：心绞痛, 不稳定型, 经皮冠状动脉介入治疗, 预后

Abstract：【Objective】To explore the correlation between neutrophil extracellular traps (NETs) and short-term prognosis in patients with unstable angina pectoris (UAP) undergoing percutaneous tubular intervention (PCI). 【Methods】A total of 215 patients with UAP who underwent PCI treatment in our hospital from September 2019 to September 2023 were selected. Based on the prognosis within 30 days after PCI, the patients were divided into a good prognosis group (n=138) and a poor prognosis group (n=77). The serum dsDNA/NETs, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), myeloperoxidase (MPO), creatine kinase isoenzyme MB (CK-MB), cardiac troponin I (cTnI), as well as platelet count, white blood cell count, and mean platelet volume (MPV) were compared between the two groups. Pearson method was used to analyze the relationship of serum dsDNA/NETs with various indicators. Logistic regression model was used to analyze the risk factors for adverse cardiovascular events in UAP patients after PCI. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of 24-hour serum dsDNA/NETs level for adverse cardiovascular events in UAP patients. 【Results】The serum levels of dsDNA/NETs, CRP, CK-MB, cTnI, TNF-α, IL-10, and MPO at 24 hours after surgery in both groups were higher than those before surgery, while these parameters in the poor prognosis group were higher than those in the good prognosis group. The levels of MPV and PLT in both groups were lower than those before surgery, and the MPV and PLT levels of the poor prognosis group were lower than those of the good prognosis group, with statistical significance (P<0.05). The serum dsDNA/NETs level in UAP patients was negatively correlated with MPV and PLT levels at 24 hours after surgery (r=-0.382, -0.527, both P<0.05). Multivariate logistic regression analysis showed that high levels of dsDNA/NETs, CRP, CK-MB, and low level of MPV were risk factors for poor prognosis after PCI in UAP patients (P<0.05). The area under the curve of serum dsDNA/NETs level in predicting adverse prognosis of UAP patients after PCI was 0.860, with a sensitivity of 84.40% and a specificity of 83.80%. 【Conclusion】Serum dsDNA/NETs level is significantly higher in UAP patients after PCI, which can be used to evaluate the occurrence of short-term adverse cardiovascular events in UAP patients after PCI.

Key words： Angina, Unstable Percutaneous Coronary Intervention Prognosis

收稿日期: 2024-12-13

中图分类号:

R541.4

引用本文:

陈建国. NETs与不稳定型心绞痛患者PCI术后短期预后的相关性[J]. 医学临床研究, 2025, 42(7): 1146-1149.
CHEN Jianguo. Relationship of Serum Neutrophil Extracellular Traps with Short-Term Prognosis in Patients with Unstable Angina Pectoris after Percutaneous Coronary Intervention. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1146-1149.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.07.012 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I7/1146

[1] 高翔宇, 陈晖, 丁晓松, 等. 入院即刻N末端B型利钠肽原对不稳定型心绞痛患者左心室射血分数和院内主要不良心脑血管事件的预测价值[J].中华心血管病杂志, 2019, 47(2): 117-122.
[2] 周金英, 刘臣, 周鹏, 等. 接受急诊介入治疗急性冠状动脉综合征患者的临床特征和变化趋势分析[J].中华心血管病杂志, 2018, 46(10): 790-794.
[3] DENTALI F, NIGRO O, SQUIZZATO A, et al. Impact of neutrophils to lymphocytes ratio on major clinical outcomes in patients with acute coronary syndromes: A systematic review and meta-analysis of the literature[J].Int J Cardiol,2018, 266(1): 31-37.
[4] LIM H H, JEONG I H, AN G D, et al. Evaluation of neutrophil extracellular traps as the circulating marker for patients with acute coronary syndrome and acute ischemic stroke[J].J Clin Lab Anal,2020, 35(5): e23190.
[5] PERTIWI K R, WAL A D, PABITTEI D R, et al. Neutrophil extracellular traps participate in all different types of thrombotic and haemorrhagic complications of coronary atherosclerosis[J].Thromb Haemost,2018, 118(6): 1078.
[6] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会. 非ST段抬高急性冠状动脉综合征诊断和治疗指南[J].中华心血管病杂志, 2012, 40(5): 353-367.
[7] 何照国,邹洋. 丹参川芎嗪注射液联合曲美他嗪对不稳定型心绞痛患者心电图、心功能的影响[J].医学临床研究, 2024, 41(5): 747-749.
[8] WANG J, XU W J, ZHAO H H, et al. Identification of potential plasma biomarkers and metabolic dysfunction for unstable angina pectoris and its complication based on global metabolomics[J].Biosci Rep,2019, 39(3): BSR20181658.
[9] 佟潇, 寇俊杰. 中性粒细胞胞外诱捕网在冠心病发病机制中作用研究的进展[J].心血管康复医学杂志, 2018, 27(5): 109.
[10] DUCROUX C, MEGLIO L D, LOYAU S, et al. Thrombus Neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke[J].Stroke,2018, 49(3): 754-757.
[11] CAROLYN W, ALEXANDER J, VASILENA C, et al. Targeting of cell-free DNA by DNase I diminishes endothelial dysfunction and inflammation in a rat model of cardiopulmonary bypass[J].Sci Rep,2019, 9(1): 19249.
[12] VULESEVIC B, LAVOIE S S, NEAGOE P E, et al. CRP induces NETosis in heart failure patients with or without diabetes[J].Immunohorizons,2019, 3(8): 378-388.
[13] HOFBAUER T M, MANGOLD A, SCHERZ T, et al. Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction[J].Archiv Für Kreislaufforschung,2019, 114(5): 33.
[14] LEANDRA L L, JAIRO R T, MARCELO R A, et al. Neutrophil extracellular trap-enriched supernatants carry microRNAs able to modulate TNF-α production by macrophages[J].Sci Rep, 2020, 10(1): 2715.
[15] BENSON T W, WEINTRAUB N L, KIM H W, et al. A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome[J].Lab Invest,2018, 98(10): 1300-1310.
[16] LIU J, YANG D D, WANG X Q, et al. Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction[J].Sci Rep,2019, 9(1): 11599.