Abstract：【Objective】To explore the effects of Simotang combined with Bifidobacterium BB-12 on intestinal flora and digestive function in children with constipation. 【Methods】A total of 100 children with constipation admitted to our hospital from July 2021 to July 2023 were selected and divided into the control group and the observation group by random number table method, with 50 cases in each group. The control group was treated with Simotang Oral Liquid, while the observation group was treated with Simotang combined with Bifidobacterium BB-12. The symptom improvement, anorectal manometry indices, gastrointestinal hormone levels and the number of intestinal flora were compared between the two groups before and after treatment. 【Results】After treatment, the defecation interval, defecation time, defecation pain score, abdominal pain and bloating symptom scores in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). After treatment, the rectal maximum volume sensory threshold, maximum anal squeeze pressure and simulated defecation anal pressure in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); there was no significant difference in rectal resting pressure between the two groups before and after treatment (P>0.05). After treatment, the serum levels of gastrin and motilin in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05); there was no significant difference in serum somatostatin and vasoactive intestinal peptide levels between the two groups before and after treatment (P>0.05). After treatment, the numbers of lactobacilli and bifidobacteria in both groups were higher than those before treatment, and the observation group was higher than the control group; the numbers of enterobacteria and staphylococci in both groups were lower than those before treatment, and the observation group was lower than the control group, with statistically significant differences (P<0.05). 【Conclusion】 Simotang combined with Bifidobacterium BB-12 can effectively improve intestinal flora imbalance in children and promote the recovery of gastrointestinal digestive function, which is worthy of clinical reference.
王青青. 四磨汤联合乳双歧杆菌BB-12对便秘患儿肠道菌群和消化功能的影响[J]. 医学临床研究, 2025, 42(7): 1150-1152.
WANG Qingqing. Effects of Simotang Combined with Bifidobacterium BB-12 on Intestinal Flora and Digestive Function in Children with Constipation. JOURNAL OF CLINICAL RESEARCH, 2025, 42(7): 1150-1152.
2025, Vol. 42 
