创伤性颅脑损伤患者血清S100β、NSE水平与颅脑损伤程度和预后的关系

doi:10.3969/j.issn.1671-7171.2025.06.032

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摘要【目的】探讨创伤性颅脑损伤(TBI)患者血清S100钙结合蛋白β(S100β)、神经特异性烯醇化酶(NSE)水平与颅脑损伤程度和预后的关系。【方法】根据格拉斯哥昏迷量表(GCS)评分将116例TBI患者分为轻度组(n=53)、中度组(n=38)、重度组(n=25),根据患者预后情况分为预后良好组(n=95)和预后不良组(n=21)。比较各组患者的血清S100β、NSE水平,构建受试者工作特征(ROC)曲线,分析血清S100β、NSE对患者预后的预测价值。【结果】轻度组患者S100β、NSE水平低于中度组,中度组低于重度组,且各组比较,差异均有统计学意义(P<0.05)。预后不良组患者S100β、NSE水平高于预后良好组(P<0.05)。ROC曲线结果显示,血清S100β、NSE联合预测的曲线下面积(AUC)值明显优于S100β、NSE单独预测的AUC值。【结论】TBI患者血清S100β、NSE水平随着病情的严重程度增加而逐渐升高,其对TBI患者的预后具有较好的预测价值。

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	李柯
	李斌
	黄永杰

关键词 ：颅脑损伤, S100蛋白质类, 磷酸丙酮酸水合酶, 预后

Abstract：【Objective】To investigate the relationship of serum levels of S100 calcium-binding protein β (S100β) and neuron-specific enolase (NSE) with the severity and prognosis in traumatic brain injury (TBI) patients.【Methods】A total of 116 TBI patients were categorized into three groups based on the Glasgow Coma Scale (GCS) score: mild group(n=53), moderate group(n=38), and severe group(n=25). They were also grouped by prognosis into the favorable prognosis (n=95) and the poor prognosis (n=21) groups. Serum levels of S100β and NSE were compared across these groups. Receiver operating characteristic (ROC) curves were constructed to assess the predictive value of serum S100β and NSE levels for patient prognosis.【Results】 Serum S100β and NSE levels in the mild group were significantly lower than those in the moderate group, while the levels of serum S100β and NSE in the moderate group were lower than those in the severe group (P<0.05). Patients in the poor prognosis group had significantly higher S100β and NSE levels than those in the favorable prognosis group (P<0.05). ROC analysis showed that the area under the curve (AUC) for the combined prediction using both S100β and NSE was significantly higher than that of either marker alone.【Conclusion】 Serum levels of S100β and NSE in TBI patients increase with the severity of the condition. They both have good predictive value for patient prognosis.

Key words： Craniocerebral Trauma S100 Proteins Phosphopyruvate Hydratase Prognosis

收稿日期: 2025-02-19

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R651.15

引用本文:

李柯, 李斌, 黄永杰. 创伤性颅脑损伤患者血清S100β、NSE水平与颅脑损伤程度和预后的关系[J]. 医学临床研究, 2025, 42(6): 1027-1029.
LI Ke, LI Bin, HUANG Yongjie. Relationship of Serum S100β and NSE Levels with the Severity and Prognosis in Traumatic Brain Injury Patients. JOURNAL OF CLINICAL RESEARCH, 2025, 42(6): 1027-1029.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2025.06.032 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2025/V42/I6/1027

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