Clinical Efficacy of Catheter-Directed Thrombolysis Combined with Stent Implantation in Patients with Cockett Syndrome and Lower Limb Deep Vein Thrombosis
LIN Songruo, TANG Wenxian, JIANG Weiqing
Department of General Surgery, Yangpu District Central Hospital, Shanghai 200090
Abstract：【Objective】To investigate the therapeutic effect of catheter-directed thrombolysis combined with stent implantation in the treatment of patients with Cockett syndrome and lower limb deep vein thrombosis (DVT). 【Methods】A total of 104 patients with Cockett syndrome and lower limb deep vein thrombosis admitted to our hospital from March 2020 to March 2023 were randomly divided into the observation group and the control group using a random number table method, with 52 patients in each group. The control group received catheter contact thrombolysis treatment, while the observation group received catheter contact thrombolysis combined with stent implantation treatment. The thrombus clearance rate, inflammatory factors [tumor necrosis factor-α(TNF-α), C-reactive protein (CRP), interleukin-10 (IL-10)], degree of phlebitis [venous clinical severity scale (VCSS) score], quality of life [quality of life questionnaire (CIVIQ)], incidence of complications and recurrence were compared between the two groups. 【Results】The proportion of thrombus clearance rate of grade Ⅲ in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). One month after surgery, the levels of serum TNF-α, CRP, and IL-10 in both groups of patients were higher than before surgery. The levels of serum TNF-α, CRP, and IL-10 in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The VCSS scores of the two groups were lower than those before surgery, and the CIVIQ scores were higher than those before surgery. The observation group had lower VCSS score than the control group and higher CIVIQ score than the control group, with statistically significant differences (P<0.05). The recurrence rate of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of complications between the two groups (P>0.05). 【Conclusion】Catheter-directed thrombolysis combined with stent implantation for the treatment of Cockett syndrome with lower limb DVT significantly improves thrombus clearance, reduces inflammatory marker levels, alleviates vein inflammation, enhances quality of life, and lowers recurrence rates, without increasing the incidence of complications.
2025, Vol. 42 
