The Application Value of 3.0T Magnetic Resonance Histo Technology and Multi-Echo Dixon Technology in the Quantitative Analysis of Non-Alcoholic Fatty Liver Disease in Obese Children
TANG Jing, LI Chunwang, CAI Qifang, et al
Hunan Children's Hospital, Affiliated Children's Hospital, Xiangya School of Medicine, Central South University, Changsha Hunan 410007
Abstract：【Objective】To explore the application value of 3.0T magnetic resonance Histo technology and multi-echo Dixon technology in the quantitative analysis of non-alcoholic fatty liver disease(NAFLD) in obese children. 【Methods】 A total of 137 children aged 7 to 15 years who were diagnosed as obese in the Department of Child Health Care of our hospital from December 2021 to December 2023 were prospectively selected, and 40 non-obese healthy children of the same age group who underwent physical examinations in our hospital during the same period (the healthy control group) were selected. According to the diagnosis and treatment guidelines for non-alcoholic fatty liver disease, obese children were divided into the simple obesity group (n=45), the NAFLD group (n=42), and the non-alcoholic steatohepatitis group (NASH group, n=50). All the research subjects underwent 3.0T magnetic resonance Histo and multi-echo Dixon technique examinations. The magnetic resonance spectroscopy-proton density fat fraction (MRS-PDFF) and magnetic resonance-proton density fat fraction (MRI-PDFF) of different groups were compared. 【Results】The MRS-PDFF and MRI-PDFF in the simple obesity group, NAFLD group and the NASH group showed an increasing trend. Comparisons among the groups showed statistically significant differences (P<0.05). The MRS-PDFF and MRI-PDFF in the simple obesity group, the NAFLD group and the NASH group were significantly higher than those in the healthy control group. The differences were all statistically significant (P<0.05). Pearson correlation analysis showed that MRS-PDFF was significantly correlated with MRI-PDFF in the healthy control group, the simple obesity group, the NAFLD group, and the NASH group (P<0.05). Spearman correlation analysis showed that there was no significant correlation between MRS-PDFFF and MRI-PDF in obese children and BMI or waist circumference/height (all P>0.05). 【Conclusion】 The 3.0T magnetic resonance Histo technique and the multi-echo Dixon technique can quantitatively assess the fat content of the liver more accurately, identify the fat infiltration of the liver at an early stage, and distinguish the degree of liver fat infiltration in different obese children.
汤静, 李春旺, 蔡齐芳, 尹一伟. 3.0T磁共振Histo技术和多回波Dixon技术在定量分析肥胖儿童非酒精性脂肪肝病中的应用价值*[J]. 医学临床研究, 2025, 42(5): 740-743.
TANG Jing, LI Chunwang, CAI Qifang, et al. The Application Value of 3.0T Magnetic Resonance Histo Technology and Multi-Echo Dixon Technology in the Quantitative Analysis of Non-Alcoholic Fatty Liver Disease in Obese Children. JOURNAL OF CLINICAL RESEARCH, 2025, 42(5): 740-743.
[1] PIAZZOLLA V A, MANGIA A. Noninvasive diagnosis of NAFLD and NASH[J].Cells,2020,9(4):1005. [2] JIA S Z, ZHAO Y Z, LIU J Q, et al. Magnetic resonance imaging-proton density fat fraction vs. transient elastography-controlled attenuation parameter in diagnosing non-alcoholic fatty liver disease in children and adolescents: a Meta-analysis of diagnostic accuracy[J].Front Pediatr,2021,9: 784221. [3] QU Y L,LI M,HAMILTON G,et al. Diagnostic accuracy of hepatic proton density fat fraction measured by magnetic resonance imaging for the evaluation of liver steatosis with histology as reference standard: a meta-analysis[J].Eur Radiol,2019,29(10):5180-5189. [4] 安梓铭,冯琴.磁共振质子密度脂肪分数:一种具有潜力的非酒精性脂肪性肝炎临床试验替代终点[J].临床肝胆病杂志, 2021,37(6): 1445-1448. [5] YURDAISIK I,NURILI F. Accuracy of multi-echo Dixon sequence in quantification of hepatic steatosis[J].Cureus,2020, 12(2): e7103. [6] BENETOLO P O, FERNANDES M I M, CIAMPO I R L D, et al. Evaluation of nonalcoholic fatty liver disease using magnetic resonance in obese children and adolescents[J].J Pediatr (Rio J),2019, 95(1): 34-40. [7] COTTER T G,RINELLA M. Nonalcoholic fatty liver disease 2020: the state of the disease[J].Gastroenterology,2020,158(7):1851-1864. [8] ZHOU F, ZHOU J H, WANG W X,et al. Unexpected rapid increase in the burden of NAFLD in china from 2008 to 2018: a systematic review and meta-analysis[J].Hepatology,2019,70(4):1119-1133. [9] TADA T,KUMADA T,TOYODA H,et al.Utility of attenuation coefficient measurement using an ultrasound—guided attenuation parameter for evaluation of hepatic steatosis:comparison with MRI: determined proton density fat fraction[J].Am J Roentgenol,2019,212(2):332-341. [10] TINCOPA M A, LOOMBA R. Non-invasive diagnosis and monitoring of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis[J].Lancet Gastroenterol Hepatol,2023,8(7):660-670. [11] MIDDLETON M S,VAN NATTA M L,HEBA E R, et al. Diagnostic accuracy of magnetic resonance imaging hepatic proton density fat fraction in pediatric non-alcoholic fatty liver disease[J].Hepatology,2018,67:858-872. [12] 王春祥,闫喆.单纯性肥胖症学龄儿童肝脏脂肪含量的MRI研究[J].国际医学放射学杂志,2019, 42(1):45-48. [13] KAZI I N, KUO L, TASI E. Noninvasive methods for assessing liver fibrosis and steatosis[J].Gastroenterol Hepatol (N Y),2024,20(1):21-29. [14] 马静,宋志强,宋琼,等.T2*校正的多回波 Dixon 技术定量分析非酒精性脂肪肝的临床应用研究[J].放射学实践, 2014, 29(4):423-427.
2025, Vol. 42 
