Effects of Different Dual Antiplatelet Therapy Regimens on Blood Lipids, Coronary Artery Blood Flow Status, and Fibrinolytic and Coagulation System Stability in Patients with Acute Myocardial Infarction after PCI
HU Yanan, HUA Pengduo, LIU Yang
Department of Cardiovascular Medicine, Nanyang Second People's Hospital, Nanyang Henan 473000
Abstract：【Objective】To explore the effects of different dual antiplatelet therapy (DAPT) regimens on blood lipids, coronary artery blood flow status, and fibrinolytic and coagulation system stability in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). 【Methods】The clinical data of 100 AMI patients who underwent PCI in our hospital from April 2022 to June 2024 were analyzed retrospectively. According to different treatment regimens, the patients were divided into an observation group (n=48, treated with aspirin + ticagrelor DAPT regimen after surgery) and a control group (n=52, treated with conventional aspirin + clopidogrel DAPT regimen after surgery). Both groups received continuous treatment for at least 24 weeks. Blood lipid indexes [triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], coronary artery blood flow status indexes [corrected TIMI frame count (CTFC), coronary flow velocity reserve (CFVR), peak systolic velocity (PSV)], and fibrinolytic and coagulation system indexes [platelet aggregation rate, fibrinogen (FIB), tissue-type plasminogen activator (t-PA), antithrombin Ⅲ (AT-Ⅲ)] were compared between the two groups. The incidence of bleeding events and major adverse cardiovascular events (MACE) during treatment was counted in both groups. 【Results】After 24 weeks of treatment, the serum levels of TG, TC, and LDL-C in both groups were lower than those before treatment, while HDL-C was higher than that before treatment; the serum HDL-C level in the observation group was higher than that in the control group, and LDL-C was lower than that in the control group, with statistically significant differences (P<0.05); there were no statistically significant differences in serum TG and TC between the two groups (P>0.05). After 24 weeks of treatment, CFVR and PSV in both groups were higher than those before treatment, and CTFC was lower than that before treatment, with statistically significant differences (P<0.05); there were no statistically significant differences in CFVR, PSV, and CTFC between the two groups (P>0.05). After 24 weeks of treatment, t-PA and AT-Ⅲ in both groups were higher than those before treatment, and platelet aggregation rate and FIB were lower than those before treatment; t-PA and AT-Ⅲ in the observation group were higher than those in the control group, and platelet aggregation rate and FIB were lower than those in the control group, with statistically significant differences (P<0.05). There were no statistically significant differences in the cumulative incidence of bleeding events and MACE between the two groups (all P>0.05). 【Conclusion】Both DAPT regimens can well improve the coronary artery blood flow status of AMI patients after PCI with high safety; however, the aspirin + ticagrelor DAPT regimen can better regulate the patients' blood lipid levels and is more conducive to the stability of the fibrinolytic and coagulation systems.
胡亚南, 华朋铎, 刘洋. 不同的双抗治疗方案对急性心肌梗死患者PCI术后血脂、冠状动脉血流状态、纤溶及凝血系统稳定性的影响[J]. 医学临床研究, 2025, 42(11): 1883-1886.
HU Yanan, HUA Pengduo, LIU Yang. Effects of Different Dual Antiplatelet Therapy Regimens on Blood Lipids, Coronary Artery Blood Flow Status, and Fibrinolytic and Coagulation System Stability in Patients with Acute Myocardial Infarction after PCI. JOURNAL OF CLINICAL RESEARCH, 2025, 42(11): 1883-1886.
2025, Vol. 42 
