血清炎症因子水平与强迫症患者认知功能的关系

doi:10.3969/j.issn.1671-7171.2024.03.008

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摘要【目的】探讨血清炎症因子水平与强迫症患者认知功能的关系。【方法】本院接受治疗的252例强迫症患者设为强迫组,并依据Yale-Brown强迫量表(Y-BOCS)评估强迫症患者症状严重程度,分为轻度强迫组(n=125)及重度强迫组(n=127);将同期来本院体检的100例健康志愿者设为对照组。比较各组血清白介素-2(IL-2)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)及五-羟色胺(5-HT)水平变化,采用神经认知成套测验(MCCB)评估各组认知功能,采用Spearman相关性检验分析血清IL-2、IL-6、IL-8、TNF-α、5-HT水平与认知功能评分的关系。【结果】强迫组信息处理速度、视觉空间工作记忆、视觉记忆、推理和问题解决评分及5-HT水平均低于对照组(P<0.05);强迫组治疗前血清IL-2、IL-6、IL-8及TNF-α水平＞强迫组治疗后＞对照组(P<0.05);重度强迫组治疗前后信息处理速度、视觉空间工作记忆、视觉记忆、推理和问题解决评分及5-HT水平均低于轻度强迫组(P<0.05),重度强迫组治疗前后IL-2、IL-6、IL-8及TNF-α水平明显高于轻度强迫组治疗前后(P<0.05);Spearman检验显示,血清IL-2、IL-6、IL-8及TNF-α水平与强迫症患者信息处理速度、视觉空间工作记忆、视觉记忆、推理和问题解决评分呈负相关(P<0.05)。【结论】血清IL-2、IL-6、IL-8及TNF-α水平是反映强迫症患者认知功能的重要炎症指标,与强迫症患者认知功能评分存在负相关性,可作为评估强迫症患者认知功能的辅助指标。

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	陈敏
	孙晓兰
	蒋丹玛

关键词 ：强迫性障碍, 炎症趋化因子类/血液, 认知, 数据相关性

Abstract：【Objective】To explore the relationship between serum inflammatory factor levels and cognitive function in patients with obsessive-compulsive disorder. 【Methods】A total of 252 patients with obsessive-compulsive disorder who were treated in our hospital were divided into the mild obsessive-compulsive disorder group(n=125) and the severe obsessive-compulsive disorder group(n=127) according to the Yale-Brown obsessive-compulsive scale(Y-BOCS). In the same period, 100 healthy people who came to our hospital for physical examination were recruited to the control group. The changes of serum levels of interleukin-2(IL-2), levels of interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-α) and serotonin 5-hydroxytryptamine(5-HT) levels were compared among different groups. The cognitive function of each group using the Neurocognitive Battery test(MCCB) was evaluated and compared as well.Spearman correlation test was used to analyzed the relationship of cognitive function score with serum levels of IL-2, IL-6, IL-8 and TNF-α. 【Results】Information processing speed, visuospatial working memory, visual memory, reasoning and problem-solving scores, and 5-HT level in the obsessive-compulsive group were lower than those in the control group(P<0.05). The serum levels of IL-2, IL-6, IL-8 and TNF-α in pre-treated obsessive-compulsive group were higher than those post-treated obsessive-compulsive group, which was greater than the control group(P<0.05). The information processing speed, visuospatial working memory, visual memory, reasoning and problem-solving scores, and 5-HT level before and after treatment in the severe obsessive-compulsive group were lower than those in the mild obsessive-compulsive group(P<0.05), while the levels of IL-2, IL-6, IL-8 and TNF-α before and after treatment in the severe obsessive-compulsive group were significantly higher than those in the mild obsessive-compulsive group(P<0.05). Spearman test showed that serum levels of IL-2, IL-6, IL-8 and TNF-α were negatively correlated with information processing speed, visual spatial working memory, visual memory, reasoning and problem-solving scores in patients with obsessive-compulsive disorder(P<0.05). 【Conclusion】Serum levels of IL-2, IL-6, IL-8 and TNF-α are important inflammatory indicators that reflect the cognitive function of patients with obsessive-compulsive disorder. IL-2, IL-6, IL-8 and TNF-α levels are negative correlation with the cognitive function score of patients with obsessive-compulsive disorder. Thus they can be used as an auxiliary diagnostic index to detect the cognitive impairment of patients with obsessive-compulsive disorder.

Key words： Obsessive-Compulsive Disorder Chemokines/BL Cognition Correlation of Data

收稿日期: 2023-12-05

中图分类号:

R749.75

通讯作者: *E-mail:13501708739@163.com

引用本文:

陈敏, 孙晓兰, 蒋丹玛. 血清炎症因子水平与强迫症患者认知功能的关系[J]. 医学临床研究, 2024, 41(3): 348-351.
CHEN Min, SUN Xiaolan, JIANG Danma. Relationship between Serum Inflammatory Factor Level and Cognitive Function in Patients with Obsessive-compulsive Disorder. JOURNAL OF CLINICAL RESEARCH, 2024, 41(3): 348-351.

链接本文:

http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2024.03.008 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2024/V41/I3/348

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