Anesthetic Effect of Dexmedetomidine in Elderly Patients with Intertrochanteric Femur Fractures and its Impact on Postoperative Cognitive Function
YANG Liangmin, XIE Xiaojuan, MA Ligang
Clinical Medical College of Henan University of Science and Technology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang Henan 471000
Abstract：【Objective】To investigate the anesthetic effects of dexmedetomidine in elderly patients undergoing surgery for intertrochanteric femur fractures and its impact on postoperative cognitive function.【Methods】In this study, 78 elderly patients undergoing surgery for intertrochanteric femur fractures were randomly divided into two groups: the control group received propofol anesthesia and sedation, while the observation group received dexmedetomidine anesthesia and sedation. Comparisons were made between the two groups in terms of surgery duration, time for sedative effect to begin, and time to recover from anesthesia; heart rate and mean arterial pressure at pre-anesthesia (T0), 10 minutes after anesthesia (T1), end of surgery (T2), and 1 hour post-surgery (T3);Mini-Mental State Examination (MMSE) scores before surgery and 3 days after surgery; levels of serum norepinephrine (NE), cortisol (COR), malondialdehyde (MDA), and superoxide dismutase (SOD) before and 3 days after surgery. 【Results】 There was no significant difference in surgery duration between the two groups (P>0.05). The onset time of sedation and recovery time after surgery in the observation group were shorter than those in the control group (P<0.05). The heart rate and mean arterial pressure at T1, T2, and T3 were lower in the observation group compared to the control group (P<0.05). Three days post-surgery, there was no significant difference in MMSE scores in the observation group compared to pre-surgery (P>0.05), while the control group showed a decrease in MMSE scores compared to pre-surgery (P<0.05). The MMSE scores of 3 days post-surgery in the observation group were higher than those in the control group (P<0.05). Three days post-surgery, the levels of serum NE, COR, MDA, and SOD in the observation group were lower than those in the control group (P<0.05).【Conclusion】 Dexmedetomidine anesthesia in elderly patients undergoing surgery for intertrochanteric femur fractures can reduce cognitive function impairment. And it is safe and reliable.
杨良民, 谢小娟, 马立刚. 右美托咪定在老年股骨转子间骨折术中的麻醉效果及对患者术后认知功能的影响[J]. 医学临床研究, 2024, 41(4): 522-525.
YANG Liangmin, XIE Xiaojuan, MA Ligang. Anesthetic Effect of Dexmedetomidine in Elderly Patients with Intertrochanteric Femur Fractures and its Impact on Postoperative Cognitive Function. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 522-525.
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2024, Vol. 41 
