PCT、CRP、AAG与老年COPD患者下呼吸道感染的相关性分析

doi:10.3969/j.issn.1671-7171.2023.08.024

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摘要【目的】探讨C反应蛋白(c-reaetive protein,CRP)、降钙素原(Procalcitonin,PCT)、α1-酸性糖蛋白(αl acid glycoprotein,AAG)与老年COPD患者下呼吸道感染的相关性。【方法】回顾性分析本院2018年1月至2021年12月收治的84例老年COPD患者的临床资料,分析患者下呼吸道感染情况,统计患者年龄、性别、体重指数(BMI)、合并疾病、血脂指标、慢性阻塞性肺病防治(GOLD)分级、凝血指标及PCT、 CRP、AAG水平等一般资料;采用多因素Logistic回归分析影响老年COPD患者下呼吸道感染的独立危险因素;采用Spearman检验分析PCT、 CRP、AAG与老年COPD患者下呼吸道感染的相关性。【结果】84例老年COPD患者中,有50例(59.52%)患者无下呼吸道感染,纳为未感染组;有34例(40.48%)患者伴下呼吸道感染,纳为感染组。两组年龄、性别、合并疾病、血脂指标、BMI、凝血指标、GOLD分级、吸烟史、病程比较,差异无统计学意义(P>0.05);感染组PCT、 CRP、AAG水平均高于未感染组(P<0.05)。多因素Logistic回归分析显示:CRP、PCT、AAG是影响老年COPD患者下呼吸道感染的独立危险因素(P<0.05)。Spearman检验结果显示:血清PCT、 CRP、AAG水平与老年COPD患者下呼吸道感染呈正相关(P<0.05)。【结论】PCT、 CRP、AAG是影响老年COPD患者下呼吸道感染的危险因素,随着PCT、 CRP、AAG水平升高,老年COPD患者发生下呼吸道感染的风险也相应增加。

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	余蕊
	谢军

关键词 ：肺疾病,慢性阻塞性/并发症, 呼吸道感染/并发症, 降钙素原/血液, C反应蛋白质/血液, 血清类黏蛋白

Abstract：【Objective】To investigate the association of lower respiratory tract infection with PCT (Procalcitonin),CRP (c-reactive protein) and AAG (αl acid glycoprotein) in geriatric patients with COPD.【Methods】Clinical profiles of 84 geriatric patients with COPD admitted to our hospital from January 2018 to December 2021 were retrospectively analysed. Lower respiratory tract infection stauts age,gender,BMI,comorbidity,blood lipid index,chronic obstructive pulmonary disease prevention and treatment (GOLD) grade,coagulation index,and level of PCT,CRP and AAG were collected. Multivariate logistic regression analysis was used to analyze the independent risk factors of lower respiratory tract infection in elderly patients with COPD; Spearman test was used to analyze the correlation of lower respiratory tract infection with PCT,CRP and AAG in elderly patients with COPD. 【Results】Among 84 elderly patients with COPD,50 patients (59.52%) were admitted as uninfected group with no lower respiratory tract infection and 34 patients (40.48%) were admitted to the infection group with lower respiratory tract infection. There was no statistically significant difference in age,gender,comorbidities,blood lipid indicators,BMI,coagulation indicators,GOLD grading,smoking history,and disease course between the two groups (P>0.05). The levels of PCT,CRP,and AAG in the infection group were higher than those in the non-infection group (P<0.05). Multivariate logistic regression analysis showed that CRP,PCT and AAG were independent risk factors for lower respiratory tract infection in elderly patients with COPD (P<0.05). Spearman test showed that serum levels of PCT,CRP and AAG were positively correlated with lower respiratory tract infection in elderly patients with COPD (P<0.05). 【Conclusion】PCT,CRP and AAG are the risk factors for lower respiratory tract infection in geriatric patients with COPD. With the increase of PCT,CRP and AAG levels,the risk of lower respiratory tract infection in elderly patients with COPD increases accordingly.

Key words： Pulmonary Disease,Chronic Obstructive/CO Respiratory Tract Infections/CO Procalcitonin/BL C-Reactive Protein/BL Orosomucoid

收稿日期: 2022-10-06

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R563

通讯作者: ^*E-mail:763132116@qq.com

引用本文:

余蕊, 谢军. PCT、CRP、AAG与老年COPD患者下呼吸道感染的相关性分析[J]. 医学临床研究, 2023, 40(8): 1204-1206.
YU Rui, XIE Jun. Correlation Analysis of Lower Respiratory Tract Infection with PCT,CRP and AAG in Geriatric Patients with COPD. JOURNAL OF CLINICAL RESEARCH, 2023, 40(8): 1204-1206.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2023.08.024 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2023/V40/I8/1204