Abstract：【Objective】To explore the clinical effect of the Spleen and kidney Tonifying Recipe on the intervention of spleen and kidney deficiency syndrome in perimenopausal syndrome. 【Methods】A total of 80 patients with spleen and kidney deficiency syndrome admitted to Hunan Maternal and Child Health Hospital from February 2020 to February 2021 were randomly divided into an observation group and a control group, with 40 cases in each group. The observation group was treated with the self-made the Spleen and kidney Tonifying Recipe, and the control group was treated with estradiol/estradiol Dydrogesterone tablets orally, 28 days as a cycle, 3 consecutive cycles. The symptom score, clinical efficacy, endometrial thickness, uterine volume, ovarian volume, serum endocrine hormone [Luteinizing hormone (LH), Follicle-stimulating hormone (FSH), estradiol (E2)] levels, Calcitonin (CT), parathyroid hormone (PTH), β-Endorphins(β-EP), interleukin-2 (IL-2), and bone mineral density of the forearm, hip joint, and L1-4 lumbar spine were compared.【Results】The scores and total scores of hot flashes, sweating, abnormal sensation, insomnia, depression, anxiety, dizziness, fatigue, muscle Arthralgia, headache, palpitations, skin ants, vulva/vagina discomfort, urinary irritation symptoms in the observation group were lower than those in the control group (P<0.05). The total effective rate of patients in the observation group was 95.00% (38/40), significantly higher than 70.00% (28/40) in the control group, and the difference was statistically significant(χ2=8.658, P<0.05). The serum FSH level in the observation group was lower than that in the control group (P<0.05), while the serum E2 level was higher than that in the control group (P<0.05). The bone mineral density of the forearm, hip joint, and L1-4 lumbar vertebrae in the observation group was higher than that in the control group (P<0.05). The serum levels of CT,β-EP, and IL-2 in the observation group were higher than those in the control group (P<0.05), while the serum PTH levels were lower than those in the control group (P<0.05). 【Conclusion】The Spleen and Kidney Tonifying Recipe has a significant clinical effect on the treatment of perimenopausal syndrome with spleen and kidney deficiency syndrome, which can improve symptoms, hormone levels, immune function, and bone density of patients. It is worth promoting and applying in clinical practice.
梁松岳, 罗岚. 补脾益肾方干预围绝经期综合征脾肾两虚证患者的临床效果[J]. 医学临床研究, 2023, 40(7): 972-975.
LIANG Song-yue, LUO Lan. Clinical Effect of the Spleen and Kidney Tonifying Recipe on Intervention of Perimenopausal Syndrome with Spleen and Kidney Deficiency Syndrome. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 972-975.
2023, Vol. 40 
