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医学临床研究  2022, Vol. 39 Issue (9): 1392-1394    DOI: 10.3969/j.issn.1671-7171.2022.09.031
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围绝经期综合征女性卵巢储备功能与甲状腺功能的相关性分析
思美丽1, 史帆2*
1.榆林市第二医院妇科,陕西 榆林 719000;
2.子洲县人民医院妇产科,陕西 榆林 718499
Relationship between Ovarian Reserve Function and Thyroid Function in Women with Perimenopausal Syndrome
SI Mei-li, SHI Fan
Department of Gynaecology,Yulin No.2 Hospital,Yulin Shaanxi 719000
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摘要 【目的】探讨围绝经期综合征女性卵巢储备功能与甲状腺功能的相关性。【方法】选取2020年1月至2022年1月在榆林市第二医院诊治的80例围绝经期综合征患者,根据患者是否存在卵巢储备功能下降分为观察组(存在卵巢功能下降,n=50)和对照组(未存在卵巢功能下降,n=30)。收集两组入院时年龄、体重指数(BMI)、血型、吸烟史、初潮年龄、初次性生活、初次妊娠年龄、痛经史、经期、月经周期、流产次数、孕次、盆腔炎、睡眠质量等资料,两组均在入院时检测促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平。采用受试者工作特征(ROC)曲线分析TSH、FT3、FT4水平对围绝经期综合征女性患者卵巢储备功能下降的预测价值,采用非条件Logistic逐步回归分析围绝经期综合征女性患者卵巢储备功能下降的危险因素。【结果】观察组TSH、FT3、FT4水平显著高于对照组,差异有统计学意义(P<0.05)。TSH、FT3、FT4水平预测围绝经期综合征女性患者卵巢储备功能下降的ROC曲线下面积分别为0.879、0.987、0.924。多因素Logistic回归分析显示:TSH≥2.516 mIU/L、FT3≥4.669 pmol/L、FT4≥15.577 pmol/L是围绝经期综合征女性患者卵巢储备功能下降的危险因素(均P<0.05)。【结论】TSH、FT3、FT4可作为预测绝经期综合征女性患者卵巢储备功能下降的指标,为此类患者的预防及治疗提供参考,值得临床医师关注。
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作者相关文章
思美丽
史帆
关键词 围绝经期/生理学综合征卵巢储备功能/生理学甲状腺功能试验    
Abstract:【Objective】To explore the relationship between ovarian reserve function and thyroid function in women with perimenopausal syndrome. 【Methods】A total of 80 patients with perimenopausal syndrome treated in our hospital from January 2020 to January 2022 were selected. According to whether the patients had ovarian reserve function decline, the observation group (with ovarian function decline, n=50) and the control group (without ovarian function decline, n=30) were selected. Age at admission, body mass index (BMI), blood type, smoking history, age at menarche, age at first sex, age at first pregnancy, history of dysmenorrhea, menstrual period, menstrual cycle, number of abortions, pregnancy times, pelvic inflammatory disease and sleep quality were collected. The levels of thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were detected in both groups at admission. The differences of basic data and laboratory indicators between the two groups were compared. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of TSH, FT3 and FT4 levels for ovarian reserve function decline in women with perimenopausal syndrome. Unconditional logistic regression was used to analyze the risk factors for ovarian reserve decline in women with perimenopausal syndrome. 【Results】The levels of TSH, FT3 and FT4 in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). The areas under the ROC curve of TSH, FT3 and FT4 levels in predicting ovarian reserve decline in women with perimenopausal syndrome were 0.879, 0.987 and 0.924, respectively. Multivariate Logistic regression analysis confirmed that TSH≥2.516 mIU/L, FT3≥4.669 pmol/L, FT4≥15.577 pmol/L were risk factors for ovarian reserve decline in women with perimenopausal syndrome (all P<0.05). 【Conclusion】TSH, FT3 and FT4 can be used as blood indicators to predict the decline of ovarian reserve function in female patients with menopausal syndrome. Thus, these parameters provide reference for the prevention and treatment of such patients, which is worthy of clinicians' attention.
Key wordsPerimenopause/PH    Syndrome    Ovarian Reserve/PH    Thyroid Function Tests
收稿日期: 2022-05-10     
中图分类号:  R271.116  
通讯作者: *E-mail:455938311@qq.com   
引用本文:   
思美丽, 史帆. 围绝经期综合征女性卵巢储备功能与甲状腺功能的相关性分析[J]. 医学临床研究, 2022, 39(9): 1392-1394.
SI Mei-li, SHI Fan. Relationship between Ovarian Reserve Function and Thyroid Function in Women with Perimenopausal Syndrome. JOURNAL OF CLINICAL RESEARCH, 2022, 39(9): 1392-1394.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2022.09.031     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2022/V39/I9/1392
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